ID Q08BW5_DANRE Unreviewed; 212 AA.
AC Q08BW5; B0EVP4; F6P797;
DT 31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE RecName: Full=Cytokine-inducible SH2-containing protein {ECO:0000256|ARBA:ARBA00021548};
GN Name=cish {ECO:0000313|EMBL:AAI24529.1,
GN ECO:0000313|Ensembl:ENSDARP00000079296,
GN ECO:0000313|RefSeq:NP_001070085.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050907-1};
GN Synonyms=cis {ECO:0000313|EMBL:CAJ13513.1,
GN ECO:0000313|RefSeq:NP_001070085.1}, CISH
GN {ECO:0000313|EMBL:ABM68033.1}, cish.a {ECO:0000313|EMBL:CBY83934.1,
GN ECO:0000313|RefSeq:NP_001070085.1}, ptk9l
GN {ECO:0000313|RefSeq:NP_001070085.1}, twf1l
GN {ECO:0000313|RefSeq:NP_001070085.1}, twf2a
GN {ECO:0000313|RefSeq:NP_001070085.1}, wu:fk57g04
GN {ECO:0000313|RefSeq:NP_001070085.1}, zgc:154062
GN {ECO:0000313|RefSeq:NP_001070085.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABM68033.1};
RN [1] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y.,
RA Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X.,
RA Look A.T., Chen Z.;
RT "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN [2] {ECO:0000313|EMBL:CAJ13513.1}
RP NUCLEOTIDE SEQUENCE.
RA Lewis R.S., O'Sullivan L.A., Ward A.C.;
RT "Identification of zebrafish cis, and its interation with stat5.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAI24529.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver {ECO:0000313|EMBL:AAI24529.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ABM68033.1}
RP NUCLEOTIDE SEQUENCE.
RA Jin H., Shao J.;
RT "Evolution of the suppressor of cytokine signaling (SOCS) family.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18029016; DOI=10.1016/j.molimm.2007.09.015;
RA Jin H.J., Shao J.Z., Xiang L.X., Wang H., Sun L.L.;
RT "Global identification and comparative analysis of SOCS genes in fish:
RT insights into the molecular evolution of SOCS family.";
RL Mol. Immunol. 45:1258-1268(2008).
RN [6] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23151342;
RA Jopling C., Sune G., Faucherre A., Fabregat C., Izpisua Belmonte J.C.;
RT "Hypoxia induces myocardial regeneration in zebrafish.";
RL Circulation 126:3017-3027(2012).
RN [7] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22412924; DOI=10.1371/journal.pone.0032777;
RA Liongue C., O'Sullivan L.A., Trengove M.C., Ward A.C.;
RT "Evolution of JAK-STAT pathway components: mechanisms and role in immune
RT system development.";
RL PLoS ONE 7:E32777-E32777(2012).
RN [8] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23300608;
RA Yin J., Shine L., Raycroft F., Deeti S., Reynolds A., Ackerman K.M.,
RA Glaviano A., O'Farrell S., O'Leary O., Kilty C., Kennedy C., McLoughlin S.,
RA Rice M., Russell E., Higgins D.G., Hyde D.R., Kennedy B.N.;
RT "Inhibition of the Pim1 oncogene results in diminished visual function.";
RL PLoS ONE 7:e52177-e52177(2012).
RN [9] {ECO:0000313|Ensembl:ENSDARP00000079296}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000079296};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [10] {ECO:0000313|Ensembl:ENSDARP00000079296, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000079296};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [11] {ECO:0000313|EMBL:CBY83934.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24835394; DOI=10.4049/jimmunol.1301376;
RA Lewis R.S., Noor S.M., Fraser F.W., Sertori R., Liongue C., Ward A.C.;
RT "Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain
RT homolog in zebrafish.";
RL J. Immunol. 192:5739-5748(2014).
RN [12] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [13] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28791256;
RA Diaz-Pascual F., Ortiz-Severin J., Varas M.A., Allende M.L., Chavez F.P.;
RT "In vivo Host-Pathogen Interaction as Revealed by Global Proteomic
RT Profiling of Zebrafish Larvae.";
RL Front. Cell. Infect. Microbiol. 7:334-334(2017).
RN [14] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29624168;
RA Janjuha S., Singh S.P., Tsakmaki A., Mousavy Gharavy S.N., Murawala P.,
RA Konantz J., Birke S., Hodson D.J., Rutter G.A., Bewick G.A., Ninov N.;
RT "Age-related islet inflammation marks the proliferative decline of
RT pancreatic beta-cells in zebrafish.";
RL Elife 7:e32965-e32965(2018).
RN [15] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28391457;
RA Hausen J., Otte J.C., Legradi J., Yang L., Strahle U., Fenske M.,
RA Hecker M., Tang S., Hammers-Wirtz M., Hollert H., Keiter S.H.,
RA Ottermanns R.;
RT "Fishing for contaminants: identification of three mechanism specific
RT transcriptome signatures using Danio rerio embryos.";
RL Environ. Sci. Pollut. Res. Int. 25:4023-4036(2018).
RN [16] {ECO:0000313|RefSeq:NP_001070085.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30367725;
RA Breves J.P.;
RT "Prolactin controls branchial clcn2c but not atp1a1a.2 in zebrafish Danio
RT rerio.";
RL J. Fish Biol. 94:168-172(2019).
RN [17] {ECO:0000313|RefSeq:NP_001070085.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR EMBL; CR847825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC124528; AAI24529.1; -; mRNA.
DR EMBL; EF195760; ABM68033.1; -; mRNA.
DR EMBL; AM040611; CAJ13513.1; -; mRNA.
DR EMBL; FR749998; CBY83934.1; -; mRNA.
DR RefSeq; NP_001070085.1; NM_001076617.2.
DR STRING; 7955.ENSDARP00000079296; -.
DR PaxDb; 7955-ENSDARP00000079296; -.
DR Ensembl; ENSDART00000084861; ENSDARP00000079296; ENSDARG00000060316.
DR Ensembl; ENSDART00000084861.5; ENSDARP00000079296.4; ENSDARG00000060316.6.
DR GeneID; 767678; -.
DR KEGG; dre:767678; -.
DR AGR; ZFIN:ZDB-GENE-050907-1; -.
DR CTD; 1154; -.
DR ZFIN; ZDB-GENE-050907-1; cish.
DR eggNOG; KOG4566; Eukaryota.
DR HOGENOM; CLU_079452_4_1_1; -.
DR OMA; RIQYSCA; -.
DR OrthoDB; 5362214at2759; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000000437; Chromosome 6.
DR Bgee; ENSDARG00000060316; Expressed in mature ovarian follicle and 35 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IBA:GO_Central.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0045647; P:negative regulation of erythrocyte differentiation; IMP:ZFIN.
DR GO; GO:1903707; P:negative regulation of hemopoiesis; IMP:ZFIN.
DR GO; GO:0045620; P:negative regulation of lymphocyte differentiation; IMP:ZFIN.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IMP:ZFIN.
DR GO; GO:0046426; P:negative regulation of receptor signaling pathway via JAK-STAT; IMP:ZFIN.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd10718; SH2_CIS; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR035887; CIS_SH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155:SF9; CYTOKINE-INDUCIBLE SH2-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 51..168
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 163..211
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 212 AA; 23928 MW; 025A631FFDFAE2DD CRC64;
MILCVEGPSP RALLPFSSPR RIDEPFLTIE DASKDYRALT LNFSYLDASG WYWGGISASE
AHSVLKGASE GTFLIRDSSH PDYMLTLSVK TVRGPTNVRI EYRQCRFSLD SSSPARSHLQ
SFPDVHSLVQ HYVGSKSEKN EEKMEEAHHV ISSAPKECSV LLKLKKPIHC PQGFPSLKHL
TRLVINKHTS STEMLPLPNP LLYYLQNYPF QL
//
