ID   Q090H3_STIAD            Unreviewed;      2009 AA.
AC   Q090H3;
DT   31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2006, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   SubName: Full=Alpha-2-macroglobulin family N-terminal region {ECO:0000313|EMBL:EAU66140.1};
GN   ORFNames=STIAU_4327 {ECO:0000313|EMBL:EAU66140.1};
OS   Stigmatella aurantiaca (strain DW4/3-1).
OC   Bacteria; Myxococcota; Myxococcia; Myxococcales; Cystobacterineae;
OC   Archangiaceae; Stigmatella.
OX   NCBI_TaxID=378806 {ECO:0000313|EMBL:EAU66140.1, ECO:0000313|Proteomes:UP000032702};
RN   [1] {ECO:0000313|EMBL:EAU66140.1, ECO:0000313|Proteomes:UP000032702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DW4/3-1 {ECO:0000313|EMBL:EAU66140.1,
RC   ECO:0000313|Proteomes:UP000032702};
RA   Nierman W.C.;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC       macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC       {ECO:0000256|ARBA:ARBA00010556}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAU66140.1}.
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DR   EMBL; AAMD01000063; EAU66140.1; -; Genomic_DNA.
DR   PATRIC; fig|378806.16.peg.5245; -.
DR   Proteomes; UP000032702; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR   CDD; cd02891; A2M_like; 1.
DR   Gene3D; 1.50.10.20; -; 1.
DR   Gene3D; 2.60.40.1930; -; 1.
DR   InterPro; IPR011625; A2M_N_BRD.
DR   InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR   InterPro; IPR011626; Alpha-macroglobulin_TED.
DR   InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR   InterPro; IPR041203; Bact_A2M_MG5.
DR   InterPro; IPR041246; Bact_MG10.
DR   InterPro; IPR001599; Macroglobln_a2.
DR   InterPro; IPR002890; MG2.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR   PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00207; A2M; 1.
DR   Pfam; PF07703; A2M_BRD; 1.
DR   Pfam; PF17973; bMG10; 1.
DR   Pfam; PF11974; bMG3; 1.
DR   Pfam; PF17972; bMG5; 1.
DR   Pfam; PF01835; MG2; 1.
DR   Pfam; PF07678; TED_complement; 1.
DR   SMART; SM01360; A2M; 1.
DR   SMART; SM01359; A2M_N_2; 1.
DR   SMART; SM01419; Thiol-ester_cl; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1100..1242
FT                   /note="Alpha-2-macroglobulin bait region"
FT                   /evidence="ECO:0000259|SMART:SM01359"
FT   DOMAIN          1301..1390
FT                   /note="Alpha-2-macroglobulin"
FT                   /evidence="ECO:0000259|SMART:SM01360"
FT   REGION          71..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          135..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..171
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2009 AA;  218456 MW;  DE7F87A32E51AEDC CRC64;
     MGSTMGAGLL LLKYQTSKHL QAAWGKWPGP LTRARGAPSV RRGHCLRGAG AFRGSLDTVW
     APRRAGGAVE PWVHNHTSPK TWRRSPGMPR EVSKPSFGGN MKPQSLKTPS LPRPARARWL
     VAALLVGTAL AGCKKEEGAS PATPGTSSTP PGPVSPGTSA PATPAGAEPP KPEAYTPTIR
     EVGPAEGVVP NQLVFEFPRN VQYSSGDGTA GTVIQVTPPV AGQLEYYRDN TALSLTPGNG
     FELGTTYTVS VEAVETPAGV VKPPQPGQWS YTFTTPAFAF LRMAPRQVDT DKGLVTVDLV
     FSGPVDVAKA RRYSAFLVDG KPLTTFKLST DPQHRHVLSA QLSSPLLKPG IRVDYALKAG
     LTSLRGGGAA PVGKGSFELL GGKRLDITRV SVEEGNSGFY LEVQCRDVEM NAPLSQEYDH
     WYYSNQPGCV FDEDVAAEAI HFTPPVKFSL APAHRGFRIF GDFKRGKYAM KIDAGAISEG
     NGRLLADFEN TYSISARKPQ LSFTSSGRYL PRSAWRNLPL SHLNVDEAEL TVRQVPPENL
     IFWMSNDSQE TADERTSNVL IHQMLPLKGA RDVLSTTYLD VGSMVPASTR GLVEVSVSRD
     NTRASTRILL TDLSLVAKRG AISQTVPGQE EVLVWVLGME STEPLTGVEV SLVKKSGQAV
     ARCTTSGAEG CKLQVPGQTV DPNAPFALVA RKDGELTYLK YSELKTEIAN SDVQGEPYRA
     QVPYRASIYS DRGVYRPGDT AHVAAVLRGQ EGVAPPVDLP VELRVVDPRE REFKKVSLKT
     NEAGLVSLDL PFASFQDTGR YRVVLRVADR EVAQYSLSVE EFVPERMKVT ASTEKPGYAQ
     RAPVPVMVEA AYLFGGSAEG SPVEVTCRLE PSTFTPKENA QFAYGVWRQG GTEAKAVTLG
     QVKGELNAKG QAVLDCPAQE ATGGFKGPAK LVAQASVFEA GSGRSTVGEA TVPMHPEQYY
     VGLQTGIQKV EANKPFTVTG VVVDWEGRLI TDARSLKPLE VEYLRLEEEY GSFYDESEGY
     ERYQRYLRPV REGKGTAKVE GGKFQLQVTP TQDSAGFIVR VRSGGAQTDL QLEGRGEYYW
     WGDGEERVDQ TPRPMKPTSI ALDLPRSGKV GEPVTVKLKA PYRGRVLLTA ETDQVIAAEW
     KAVEPGEVSW SFTPKGFAPN IYISAFMVKD PHLESAQAFM PDRAFGVGNV TLEPTDFTQT
     VKLAVPEEVR SNSTLTVNLE LGALEGPTYA TVAVVDEGIL SLTRFQSPDP LKELFAKRAL
     GVETYETIGW TLLVPPAGNS RSTGGDEGGD ASGRVQPVKP VALWSGVVPV PANGKLSLPF
     QLPQYRGAVR VMAVTTGAKR VGRASAQVLV RDPLVLQTTL PRFLTQDDEI QIPVFLTNLS
     GSTQEVKVSL TAENLPVPGM AMPAASMGSP LRLLGKSEGR TKLENGKAAT LVFQAKAIMA
     VGAARLKVTA EGGGHTAFEQ LDVPLLPAGP RERKVQRLEL AAGRMDLTPY LQGWVPTTER
     STFWVTTNPY AESLQHLSYL IRYPYGCIEQ TTSSTRPLLF VSQLIDNVDP SLTGDKKVED
     MVMAGVNRII SMQTPSGGFG YWPGSTEPVA WGTAYATHML LDAQKLKYPV PQDRLDDALA
     WMGQELTRKE GSSVRDNHYG REAEPYMHYV LAMAGKGRKA RVQKMVEELA SQKALSGEER
     EQEYMLKTAL YLAGDRRYEK DLRNPVLEPV TDERRNSWSF YSDRRRRGFM LSTFQDLFGN
     DPTGESLAQQ VAQGLQGHSS GWYTTQELVW GITGLGKRVS GAASDFTPPT LVADGKEVAP
     QASGGAKTAR ASDKTWALVR ASERSGVALD LKEKGEGKLY LILNSDGVRT GGQVKTGGEG
     LSIRRTYRKL DGTPVRPGEA VNLADLLYVE VELSNTTGER IQNIALVDRL PAGWEIENAR
     LGRGGSVEWV DTESLWTADY VNIRDDRMEV FGHLEARESK KVVYAVRAVT SGKFTLPPVE
     AEAMYDPRIW AREAGQQVEV SGPWKDFLL
//