ID Q0AL23_MARMM Unreviewed; 504 AA.
AC Q0AL23;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ABI67020.1};
DE Flags: Precursor;
GN OrderedLocusNames=Mmar10_2734 {ECO:0000313|EMBL:ABI67020.1};
OS Maricaulis maris (strain MCS10).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Maricaulales; Maricaulaceae;
OC Maricaulis.
OX NCBI_TaxID=394221 {ECO:0000313|EMBL:ABI67020.1, ECO:0000313|Proteomes:UP000001964};
RN [1] {ECO:0000313|EMBL:ABI67020.1, ECO:0000313|Proteomes:UP000001964}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCS10 {ECO:0000313|EMBL:ABI67020.1,
RC ECO:0000313|Proteomes:UP000001964};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Saunders E., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Viollier P.,
RA Stephens C., Richardson P.;
RT "Complete sequence of Maricaulis maris MCS10.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP000449; ABI67020.1; -; Genomic_DNA.
DR RefSeq; WP_011644664.1; NC_008347.1.
DR AlphaFoldDB; Q0AL23; -.
DR STRING; 394221.Mmar10_2734; -.
DR KEGG; mmr:Mmar10_2734; -.
DR eggNOG; COG0446; Bacteria.
DR HOGENOM; CLU_022247_1_0_5; -.
DR OrthoDB; 462203at2; -.
DR Proteomes; UP000001964; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001964}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 79
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 335
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 344
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 348
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 504 AA; 56071 MW; 9B7E6D78DA26F94E CRC64;
MKPNRIKSVL IVGGGTAGWM AAAALSRFLG PSLSITLVES DQIATVGVGE ATIPQIKHLN
AALGIEERDF VARTNGSFKL GIEFIDWHRK GAAYLHNFGS IGLNLQQVPF HHYWLRERSE
GATTSLWDYC LNTAAARDMR FAPMEKVGSS PLSGIGYAYH FDATLYGRFL REYAEQRGVS
RIEGLIETCR QDPQTGDVSK VCLQDGRELA ADLFIDCSGF RGLLIEQALE TGYEDWTHWL
PCDRAIPVPS SNEAAPIRPY TQSIAHKAGW QWRIPLQHRT GNGHVFSSAH MSEAEATDTL
LDNLEGKPLA EPRMIRFVTG RRKQFWNRNV VALGLASGFL EPLESTSIHL VQSGISRLIA
MFPDGDIAAA DRTEYNRQMV LEYERVRDFI ILHYHLNERT DSDFWQDCAA MSVPDSLTAK
MDLFRANGRL YHREEDLFTD SSWLQVMLGQ GLMPRGYHPI ADALPSDQLA GFLGDILKIV
GQAAATLPPH ADYLARHCPA AADA
//
