ID Q0BZ67_HYPNA Unreviewed; 1715 AA.
AC Q0BZ67;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=ATP-dependent DNA helicase, RecQ family/ UvrD/REP helicase domain protein {ECO:0000313|EMBL:ABI75683.1};
GN OrderedLocusNames=HNE_2532 {ECO:0000313|EMBL:ABI75683.1};
OS Hyphomonas neptunium (strain ATCC 15444).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC Hyphomonadaceae; Hyphomonas.
OX NCBI_TaxID=228405 {ECO:0000313|EMBL:ABI75683.1, ECO:0000313|Proteomes:UP000001959};
RN [1] {ECO:0000313|EMBL:ABI75683.1, ECO:0000313|Proteomes:UP000001959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15444 {ECO:0000313|EMBL:ABI75683.1,
RC ECO:0000313|Proteomes:UP000001959};
RX PubMed=16980487; DOI=10.1128/JB.00111-06;
RA Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA Ward N.L.;
RT "Comparative genomic evidence for a close relationship between the
RT dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT crescentus.";
RL J. Bacteriol. 188:6841-6850(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP000158; ABI75683.1; -; Genomic_DNA.
DR RefSeq; WP_011647524.1; NC_008358.1.
DR STRING; 228405.HNE_2532; -.
DR KEGG; hne:HNE_2532; -.
DR eggNOG; COG0210; Bacteria.
DR eggNOG; COG0514; Bacteria.
DR HOGENOM; CLU_002862_0_0_5; -.
DR Proteomes; UP000001959; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001959}.
FT DOMAIN 319..496
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 522..673
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1102..1318
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 1123..1130
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1715 AA; 190428 MW; BDB82D6CD1702CA1 CRC64;
MQVGLDLPGL GDLLRRCVSI DLEVDPNAAK IFAFAAVRHA SDIKIAFRSP KSVTDSSLAL
NRAIDDLEEF VAPDDFLIGH NFLRFDLPQL IAVRPKLSGL TDRVIDTLWL NPLAFPKNPY
HRLVKHYQDG RLLAGQLNDP ERDARLVFEV LGNQVTALSG IDQTYPDALI AYHFLSTLGE
AQAGFDAVFT HIRKAARPDQ PRARDAVRKL LVGAACGLKV EQLIDRLSEP ARGWPTAYAL
SWISVAGGES VMPPWVRIQF PEAARIVRDL RDTRCGSSSC SWCAEKNDPK RALKSWFGFE
AFRPEPKDAE GVPLQERIVA EAMQGQSVLG ILPTGTGKSV CYQVPALSKY EKTGALTVVI
SPLVALMADQ VRGLAEAGVS GCFTINGMLS LPERQAALDA VRLGDAAILL IAPEQLRTPS
VRSVLKQREI GYWVIDEAHC ISKWGHDFRP DYRYVSRFIG EFSGDEPPAP VISLTATAKP
EVVQDIRSHF KTKIDVDLAV LDGGSVRTNL SFRVERTTKA TKFADVLQTL RSDLPQEGRS
GAIVYCSTRT GTERMADFLK AQSLEAECFH AGLTPETKRD IQERFRSGDL RIIAATNAFG
MGIDKPDIRL VIHSDVPGSL ENYMQEAGRA GRDRLPATCV LLYAEEDVER QFSLSARSRL
EKHEIAALLK AIRRLDQRLQ KDGEVVATPG EIIKEEEDRE FMRDSATDDT RVKTAVAWLE
EAGLLTREHN RTHVYPSSLK IRSVEEARAI IGNANITERR RAQLLRIVGH LVDAEPDAGV
STDELSSVSG LAASELRKAL IDLETLGIAA NDTALTAYVT VGVAETSMQK FQQALQLEKD
FIQEMEEVGA DDADGTKLTL HISGVCQRLR DQGYASVRPD VLQRMLKSIA EDGRDDSGGQ
GSLRLRKPNR STITLELQRS WRAIREIADL RRRGAELILS ALIGAVPPRT RGKDIQVATT
VGKLSAALSS DVLLASSVSN ISKLLDRSLL WLHEQEIITL GRGLTIFRPA MTLQLSPGTQ
AFTKRHFDPL ADHYTEQTTQ THVMAVFAEQ GLISMNRALS LSHDYFSLER DVFLRRWLPN
RSADLRRQTM PASWQKIVGS LGNRVQMDIV SDERDQTNVL VLAGPGSGKT KVLVHRIAFL
IRVRREDPKG ILVLAYNRHA AQEILVRLRA LIGEDAAGVN ISTCHAFAMR LVGMSFVGRS
DMQTTADFDR AIEAATQLLN GDGLTTVEAE AQRDTLVQGY RWILVDEYQD IGPNEHGLVA
AIAGRSLDDP DQRLSLFAVG DDDQNIYAFG GASVEYIRKF EADYSAKPAF LVQNYRSTRH
IIEAANQVIA PAKERMKIAH AIEIDQGRRT APKGGVLHSL DPVAQGRVQR LRVKGGSKDQ
AIAAVNELKR LSQLTPDWDW KRTAIIARQW KYLQPVRSYC EDLGIPVDMG NEDSLPLWRL
RETQALVEFI RGRLGKMVSS DELCSFIAAH PSNEWWCMLQ EAVKDLEIDI GDRSIPIDEV
LEWLAEWLKE TRQAPRGLML LSAHAAKGLE FDHVVVLDGG WDQASKNEDP DAPRRLYYVA
MTRAKQSLSL ISNSGSQLFA KGGERGEILE REVFLDPSDL ARCSRIYQSV SMRDVDLSYA
GRLKPDDPVL SAISAASIGD RVSLIWRDKS WSIETDRGIQ LARLSKAFSP PQGLKFERGE
IHACISRTKG DVSPEWLHPL QRDAWEVIIP NLTFK
//
