ID Q0C1J3_HYPNA Unreviewed; 602 AA.
AC Q0C1J3;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Efflux transporter, RND family, MFP subunit {ECO:0000313|EMBL:ABI75892.1};
GN OrderedLocusNames=HNE_1694 {ECO:0000313|EMBL:ABI75892.1};
OS Hyphomonas neptunium (strain ATCC 15444).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC Hyphomonadaceae; Hyphomonas.
OX NCBI_TaxID=228405 {ECO:0000313|EMBL:ABI75892.1, ECO:0000313|Proteomes:UP000001959};
RN [1] {ECO:0000313|EMBL:ABI75892.1, ECO:0000313|Proteomes:UP000001959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15444 {ECO:0000313|EMBL:ABI75892.1,
RC ECO:0000313|Proteomes:UP000001959};
RX PubMed=16980487; DOI=10.1128/JB.00111-06;
RA Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA Ward N.L.;
RT "Comparative genomic evidence for a close relationship between the
RT dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT crescentus.";
RL J. Bacteriol. 188:6841-6850(2006).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CP000158; ABI75892.1; -; Genomic_DNA.
DR RefSeq; WP_011646700.1; NC_008358.1.
DR AlphaFoldDB; Q0C1J3; -.
DR STRING; 228405.HNE_1694; -.
DR KEGG; hne:HNE_1694; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_13_1_5; -.
DR Proteomes; UP000001959; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 6.10.140.730; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR045800; HMBD.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30097; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR PANTHER; PTHR30097:SF4; SLR6042 PROTEIN; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR Pfam; PF19335; HMBD; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001959};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..602
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004169704"
FT DOMAIN 46..73
FT /note="Heavy metal binding"
FT /evidence="ECO:0000259|Pfam:PF19335"
FT DOMAIN 146..353
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 574..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 602 AA; 64079 MW; A4ACB69A9DB57A67 CRC64;
MNRRLLLLTV ATSAALLAAC SDASGVRSQG SSAGAGTSTD AQAASYTCPM HPHYISTDAG
GSCPICGMDL VPVSGTTASA GRGDILYYKN PMGQPDTSPV PKKDFMGMDY IPVYADEAAE
PGVVVSPEMI QTMGIRTVRA ETAAFGRSLR AFGTVETNDR LENVSVARLE GWIDTLTVRA
EGDLVRPGAL LYRVYSPDLI AAQKDYLNAF AIGNDKRIAA VRQRLRSLGM QDAAINRVAE
TRAVIERVPV YAEAGGTVAA LEVREGDYVK PGTPILRLQS YAGVWIMAAV PETDLSLIET
GFPVRLSFPS APEAPGTGVI DYIYPTIDPK TRTAQVRIEI DNADGFLRPG AYADIAIDIP
GKSHLSVPSE AVLQDSRGTQ VIIALGEGRF TGRAVTTGIQ AKGRTEILSG LTAGDEVVAS
GQFLLDSEAN LREGLAKLQG PAAVTAGPDT PLSELPVDAA TLANIDHFTD MALYFHEALT
DNYRIDARFV DPALFLGETL RARFAQTKLE PVLEEAEAAL RAAKTADDGS ALADNLARLM
TALEPWLLDG APVHYREAGL TLFKETGTGR LWLQEGTTPR NPYTDGQAEP VAWPDPMAGT
QP
//
