ID Q0CCD7_ASPTN Unreviewed; 781 AA.
AC Q0CCD7;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Methyltransferase domain-containing protein {ECO:0000259|Pfam:PF13649};
GN ORFNames=ATEG_08647 {ECO:0000313|EMBL:EAU30779.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU30779.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O(in) = H2O(out); Xref=Rhea:RHEA:29667, ChEBI:CHEBI:15377;
CC Evidence={ECO:0000256|ARBA:ARBA00034651};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family.
CC {ECO:0000256|ARBA:ARBA00006175}.
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DR EMBL; CH476606; EAU30779.1; -; Genomic_DNA.
DR RefSeq; XP_001217233.1; XM_001217232.1.
DR AlphaFoldDB; Q0CCD7; -.
DR STRING; 341663.Q0CCD7; -.
DR EnsemblFungi; EAU30779; EAU30779; ATEG_08647.
DR GeneID; 4323069; -.
DR VEuPathDB; FungiDB:ATEG_08647; -.
DR eggNOG; KOG0224; Eukaryota.
DR HOGENOM; CLU_020019_2_1_1; -.
DR OMA; IRTNHRE; -.
DR OrthoDB; 5490746at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015267; F:channel activity; IEA:InterPro.
DR GO; GO:0015791; P:polyol transmembrane transport; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00333; MIP; 1.
DR Gene3D; 1.20.1080.10; Glycerol uptake facilitator protein; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR023271; Aquaporin-like.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR000425; MIP.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR43829; AQUAPORIN OR AQUAGLYCEROPORIN RELATED; 1.
DR PANTHER; PTHR43829:SF24; MIP AQUAPORIN (EUROFUNG); 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR Pfam; PF00230; MIP; 1.
DR PRINTS; PR00783; MINTRINSICP.
DR SUPFAM; SSF81338; Aquaporin-like; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 545..578
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 590..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..139
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
FT REGION 214..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..229
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 85686 MW; E2283EBA6D2C7AB5 CRC64;
MADTPEGIVE YAYDNITEWY LQWVQSQKSP RQRYTKLLLD KLQPSPSILE LGCGPGVPIV
QMLLDHGAQV VANDISTKQI EMAKARCPGA KLVAGDMTAL TFEPASFDGV ISFYTLFHLP
RSKLKDMLAK IHGWLKPGGI FVFNLATIDE EEIHGEFLGY GMFWSSYGVD ENRAILSDVG
FDVLQVEVLH AGDGKLEEGD PDFDAEFIIT IDKMDPNDTR QDRARSTDAF RHPSPSWPPE
RNTSRDGSNT RSRRDARRRS WAVSRRSGSG LPSLTRRSSL ASRLNGKFTV AGPDETPQMC
LAHEPFVQPG YADLNPSYEQ ASNAKPVWSL AKPLPRVVRS GMVPTKDELL QARAKAQNSR
RLGVEVDPTD LERGQINPSL NPRKIVAQVE DARVQRESNL ARKILSSEAS SMRLSESLKR
ASTWGAPGQL PRVEEGEALT DSDAGQDDAL SEQSDAGEAD PLLEAGDPLD LPPIDEKACP
DDLDPLVQDL VEHEVHNHHT TWSVIRTAHR EALAECLAVF VQLTVGFCAD LAVTLADAGN
PNTTAWAWGL ATMMAIYISG GVSGAHLNPA VTVMLWFYRG FPNRKMPGYF VAQFGGAFFA
ALVAYGVYYH SIQYHRTTSL ADTGIIDSFV TSQRAPWVTP AAAFVNEFVG TAILAVAILA
LGDDQNAPPG AGMNALIVGL VITCLGLTFA YQTGGALNPS RDFGPRLALL VLGYGSDLFR
NPYWLYGPWA AAISGAFTGA FLYDFMIFTG GESPVNYPVE RTKRAMKKSR RRWERALQKA
F
//
