ID Q0CK41_ASPTN Unreviewed; 519 AA.
AC Q0CK41;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Post-SET domain-containing protein {ECO:0000259|PROSITE:PS50868};
GN ORFNames=ATEG_05943 {ECO:0000313|EMBL:EAU33704.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU33704.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854}.
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DR EMBL; CH476601; EAU33704.1; -; Genomic_DNA.
DR RefSeq; XP_001215121.1; XM_001215121.1.
DR AlphaFoldDB; Q0CK41; -.
DR STRING; 341663.Q0CK41; -.
DR EnsemblFungi; EAU33704; EAU33704; ATEG_05943.
DR GeneID; 4321531; -.
DR VEuPathDB; FungiDB:ATEG_05943; -.
DR eggNOG; KOG0068; Eukaryota.
DR HOGENOM; CLU_524758_0_0_1; -.
DR OMA; EAMIVNT; -.
DR OrthoDB; 2900331at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd12169; PGDH_like_1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR42789; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR PANTHER; PTHR42789:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090); 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
DR PROSITE; PS50868; POST_SET; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 475..491
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
SQ SEQUENCE 519 AA; 55712 MW; 50A99AB2CC551F36 CRC64;
MSKPTLAVLD DYQNIAPDHF SHLTSRIDIS YFPETLNPRI PAQHDALIAR LQPFDIILAM
RERTPLSATT LAALPNLKLL LTTGTRNLAL DTAYCAAHNI PVAGTCTRPP GVNSTVQHTW
ALILALARHV ARDDAAVKRG GWQGSLGMSL AGKTLGLVGL GKLGGQVGRI AVQAFDMRVT
AWSANLTQAA ADAQAEAQGL PAGSFVVAAS KEALFRDADV VSVHYVLSER SRGVVGAPEL
AAMKPGALLV NTSRGPLVDE AALLDTLRRG GIRGAALDVF DPEPLPADSP WRTTDWGREG
RSEVLLTPHM GYGDEQIHGC SIPSLLNSSY ISPGQFLIPI PHLIMSPIAV DPSPAPAPPT
TTTTTQPTHP NLIRVVRSPK AFGSHAESLV SLPAGAVLAK ITTATPAKKA YTSVQTGRDS
HIELNSDLVF CNHSCAPTLD FDMHKMEVRV VQNRDLHVGD HLTFFYPSSE WEMDQPFQCN
CGANSCKGVI DGAKSMKKED LAGYWLNPHI EELLKERGD
//
