ID Q0CR96_ASPTN Unreviewed; 1228 AA.
AC Q0CR96;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=ATEG_03788 {ECO:0000313|EMBL:EAU35590.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU35590.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH476598; EAU35590.1; -; Genomic_DNA.
DR RefSeq; XP_001212966.1; XM_001212966.1.
DR AlphaFoldDB; Q0CR96; -.
DR STRING; 341663.Q0CR96; -.
DR EnsemblFungi; EAU35590; EAU35590; ATEG_03788.
DR GeneID; 4318614; -.
DR VEuPathDB; FungiDB:ATEG_03788; -.
DR eggNOG; KOG0942; Eukaryota.
DR HOGENOM; CLU_002173_2_4_1; -.
DR OMA; HWLMTNR; -.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 852..1228
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1196
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1228 AA; 139289 MW; FC767634A83582E7 CRC64;
MFQSFTGNSR RPRQVNLGGR TTNPFAAYPA GRQNPHGSGP QNTLAIAQQE RLARQQERER
LNASRIIQRT WRGYRCRRTV RQTFRTEWDA REQQRSGQLP QFEELAKRSD VTLDSLTPYG
TAAECLSQLR LLVQFMEPRE NGDIVRLVWF SRAFQQTLQE VPTIATEGEW TTPLRRLARL
TLRVLQLATS PSTPAFATVP LLKLLVFLTG LIPKQVARLA QVYYSVMASL TKNIGSLADR
SHLSGDHLAH SVLALLRPIT SETLTAYEWF AKSYLTVPDL RSYLGTLDTL ANNINYKLLT
SVLGSLQSQA LDPNQTSQDV EARLWLLAYF IYFHRYALGG QAGQQAPEPE FVKVISELLN
STAVHISRRL ESEDAADEDS VERTPLHPFV KEQLVSLVNQ RSITGLLSQL QSTTLSQGEL
ADAQSDASRE AKILATYALT LLRVFPRRGD DIRMWLYLGS ATSSDQTTGG PGSRIPAIKY
FWQASRASRI FATISQDSTK VLSLLKPAND SKDARGSSMS QTERDEEWMI ILLFLELYTF
VLKVMDDEEF FSSDSSFTAS SNTQISWTKE SALPLKDIKD MTVFLKNLAF TLYWNSADLN
ENEPTTHDTG GIRSYFGSLP PPSESITSVK DLELKNKEKG LPGVTGIPLD YFKGLVTGLL
RMIHERDSRR KFLPEGHWLM TNRFDMEGFI PAVVAEEENR HQLQDDEDEE DPDSLMDDAY
YEPSLGLIGT GRAQQTRRIE ALRRRQQQAA RRKQLEAVAP RLEILRNMPF FIPFPTRVQI
FREFIYRDQM RRRQGFIDPD AWRMSVAHAS MGRLLEGRSA AQDILSRHHA NIRRESVFED
AFDQFYELGE GLKEPIQITF IDKFNTAEAG IDGGGVTKEF LTSVTNEAFR STNDSNLFEE
NDQHLLYPNP AAVERQRHLL RQLGFTEGSP EWNDGIRELL RRYEFLGRVI GKCLYEGILV
DVNFAPFFLL KWALTGGTGS AQRETAYRAN LNDLKDLDQG LYQGLLQLKN YPGDVEDFAL
NFTVTDTIPL AESESRTVTR DLKPHGSEIP VTNQNRLVYI SYIARYRLQV QPALQTNAFL
QGLGQIIQPS WLSMFNQSEL QTLVRGESGD VDVADLRRNT LYGGVYSIGD DGKEHPTVQL
FWEVMEKMTN EERQKVLRFV TSTPRAPLLG FSHLNPRFSI RDSSDDQERL PSTSTCVNLL
KLPRYTDANT LREKLLYAVN SGAGFDLS
//
