ID Q0CWI5_ASPTN Unreviewed; 403 AA.
AC Q0CWI5;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=Protein phosphatase methylesterase 1 {ECO:0000256|ARBA:ARBA00020672, ECO:0000256|PIRNR:PIRNR022950};
DE Short=PME-1 {ECO:0000256|PIRNR:PIRNR022950};
DE EC=3.1.1.- {ECO:0000256|PIRNR:PIRNR022950};
GN ORFNames=ATEG_01949 {ECO:0000313|EMBL:EAU36911.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU36911.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Demethylates proteins that have been reversibly
CC carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.
CC {ECO:0000256|ARBA:ARBA00024741}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester +
CC H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) +
CC methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-
CC COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790,
CC ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000906};
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily.
CC {ECO:0000256|ARBA:ARBA00008645, ECO:0000256|PIRNR:PIRNR022950}.
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DR EMBL; CH476596; EAU36911.1; -; Genomic_DNA.
DR RefSeq; XP_001211127.1; XM_001211127.1.
DR AlphaFoldDB; Q0CWI5; -.
DR STRING; 341663.Q0CWI5; -.
DR ESTHER; asptn-q0cwi5; PPase_methylesterase_euk.
DR EnsemblFungi; EAU36911; EAU36911; ATEG_01949.
DR GeneID; 4316554; -.
DR VEuPathDB; FungiDB:ATEG_01949; -.
DR eggNOG; KOG2564; Eukaryota.
DR HOGENOM; CLU_024818_3_0_1; -.
DR OMA; EAHHTSM; -.
DR OrthoDB; 169198at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0051723; F:protein methylesterase activity; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR016812; PPase_methylesterase_euk.
DR PANTHER; PTHR14189:SF0; PROTEIN PHOSPHATASE METHYLESTERASE 1; 1.
DR PANTHER; PTHR14189; PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR PIRSF; PIRSF022950; PPase_methylesterase_euk; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR022950};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Serine esterase {ECO:0000256|PIRNR:PIRNR022950}.
FT DOMAIN 100..357
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF12697"
FT REGION 19..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 188
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
FT ACT_SITE 214
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
FT ACT_SITE 345
FT /evidence="ECO:0000256|PIRSR:PIRSR022950-1"
SQ SEQUENCE 403 AA; 44036 MW; A95A7B78A39E7582 CRC64;
MSELQKSFAK AKLAKLPVEP PMSAMDALEE EDSSGSSTGT VTPSPSKRLF ARPDRESASS
TLSWTDFFAQ ELFLREDVAN TQITHHVYLT PPTGSGPLFV MHHGAGSSGL SFATCAEEIR
KLLPTAGVLS LDARDHGQTT VTAADGHSPV ALDLSLDTLN RDLVFVVRAT QSHMAWDSLP
DLVLVGHSLG GAVITDVARK GELGPKVLAY AVLDVVEGSA MDALQSMEQY LSTRPSRFPS
LTSGIEWHTR SRTLRNRTSA RVSVPSLLYE EEASSDPSKP WVWRTNLAET KPFWENWFIG
LSRKFLEARG GKLLLLAGTD RLDKELMIGQ MQGKYQLQVL PEAGHFIQED QPAKTAQILV
DFYKRNDRSA LVLPPKVADM QASAAMKKGG SMGNPLGRPQ DHK
//
