ID Q0IHS5_XENTR Unreviewed; 1503 AA.
AC Q0IHS5; A0A6I8RQB1; A0A6I8SNK8; F7BJ26;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Disco-interacting protein 2 homolog C {ECO:0000313|EMBL:AAI22992.1, ECO:0000313|Ensembl:ENSXETP00000041946, ECO:0000313|RefSeq:NP_001072610.1};
GN Name=dip2c {ECO:0000313|EMBL:AAI22992.1,
GN ECO:0000313|Ensembl:ENSXETP00000041946,
GN ECO:0000313|RefSeq:NP_001072610.1,
GN ECO:0000313|Xenbase:XB-GENE-1011926};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI22992.1};
RN [1] {ECO:0000313|RefSeq:NP_001072610.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI22992.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI22992.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000041946}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000041946};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000087237}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001072610.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DIP2 family.
CC {ECO:0000256|ARBA:ARBA00007735}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC122991; AAI22992.1; -; mRNA.
DR RefSeq; NP_001072610.1; NM_001079142.1.
DR RefSeq; XP_012820376.1; XM_012964922.2.
DR STRING; 8364.ENSXETP00000041946; -.
DR DNASU; 780066; -.
DR Ensembl; ENSXETT00000041946; ENSXETP00000041946; ENSXETG00000026921.
DR Ensembl; ENSXETT00000079499; ENSXETP00000087237; ENSXETG00000026921.
DR Ensembl; ENSXETT00000081202; ENSXETP00000099850; ENSXETG00000026921.
DR GeneID; 780066; -.
DR KEGG; xtr:780066; -.
DR AGR; Xenbase:XB-GENE-1011926; -.
DR CTD; 22982; -.
DR Xenbase; XB-GENE-1011926; dip2c.
DR eggNOG; KOG3628; Eukaryota.
DR HOGENOM; CLU_001345_0_0_1; -.
DR OrthoDB; 3994129at2759; -.
DR TreeFam; TF312871; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Bgee; ENSXETG00000026921; Expressed in testis and 11 other cell types or tissues.
DR CDD; cd05905; Dip2; 2.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR037337; Dip2-like_dom.
DR InterPro; IPR010506; DMAP1-bd.
DR PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR PANTHER; PTHR22754:SF33; DISCO-INTERACTING PROTEIN 2 HOMOLOG C; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF06464; DMAP_binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR PROSITE; PS51912; DMAP1_BIND; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 1..67
FT /note="DMAP1-binding"
FT /evidence="ECO:0000259|PROSITE:PS51912"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1503 AA; 165162 MW; F33EBFBF769C0EFD CRC64;
MEQALPPERR TPVTPSSSSR YHRRRSSGSR DERYRSDVHT EAVQAALAKH KERKMAVPMP
SKRRSLVVQT SMDAYTPPDT SSGSEDEGSV QGDSQGTPTS SQGSINMEHW ITQAIHGSTT
STTSSSSTQS GGSGAAHRLA DVMAQTHIEN HSAPPDVTTY TSEHSIQVER PQGSTSSRVA
PKYGNAELME TGDGVPVSSR VSAKIQQLVN TLKRPKRPPL REFFVDDFEE LLEVQQPDPN
QPKAEGAQML AMRGEQLGVV TNWPPSLEAA LQRWGTISPK APCLTTMDTN GKPLYILTYG
KLWTRSMKVA YNILHKLGTK QEPMVRPGDR VALVFPNNDP AAFMVAFYGC LLAEVVPVPI
EVPLTRKDAG SQQIGFLLGS CGVTVALTSD ACHKGLPKSP TGEIPQFKGW PKLLWFVTES
KHLSKPPRDW FPHIKDANND TAYIEYKTCK DGSVLGVTVT RIALLTHCQA LTQACGYTEA
ETIVNVLDFK KDVGLWHGIL TSVMNMMHVI SIPYSLMKVN PLSWIQKVCQ YKAKVACVKS
RDMHWALVAH RDQRDINLSS LRMLIVADGA NPWSISSCDA FLNVFQSKGL RQEVICPCAS
SPEALTVAIR RPTDDSNQPP GRGVLSMQGL TYGVIRVDSE EKLSVLTVQD VGTVMPGAIM
CSVKPDGIPQ LCRTDEIGEL CVCALATGTS YYGLSGMTKN TFEVFPMMSS GAPISEYPFI
RTGLLGFIGP AGLVFVVGKM DGLMVVSGRR HNADDIVATA LAVEPMKFVY RGRIAVFSVN
VLHDERIVIV AEQRPDSTEE DSFQWMSRVL QAIDSIHQVG VYCLALVPAN TLPKTPLGGI
HLSETKQLFL EGSLHPCNVL MCPHTCVTNL PKPRQKQPEI GPASVMVGNL VSGKRIAQAS
GRDLGQMEDN DQARKFLFLS EVLQWRAQTT PDHVLYTLLN SRGTIASSLT CSQLHKRAEK
IAVMLMERGH LQDGDHVALV YPPGIDLIAA FYGCLYAGCV PITVRPPHPQ NIATTLPTVK
MIVEVSRSAC LMTTQLICKL LRSREASAAV DIRTWPPILD TDDLPKKRPS QIYKPSDPEI
LAYLDFSVST TGMLAGVKMS HAATSAFCRS IKLQCELYPS REVAICLDPY CGLGFVLWCL
CSVYSGHQSI LIPPSELEIN PALWLLAVSQ YKVRDTFCSY SVMELCTKGL GLQTESLKAR
GLDLSRVRTC VVVAEERPRI SLTQSFSKLF KDLGLHPRAV STSFGCRVNL AICLQGTSGP
DPTTVYVDMR ALRHDRVRLV ERGSPHSLPL MESGKILPGV RIIIANPETK GPLGDSHLGE
IWVHSAHNAS GYFTIYGDES LQSDHFSSRL SFGDTQTVWA RTGYLGFLRR TELTDANGER
HDALYVVGAL DEAMELRGMR YHPIDIETSV IRAHKCVTEC AVFTWTNLLV VVVELDGSEQ
EALDLVPLVT NVILEEHYLI VGVVVVVDIG VIPINSRGEK QRMHLRDGFL ADQLDPIYVA
YNM
//
