ID Q0K2T7_CUPNH Unreviewed; 948 AA.
AC Q0K2T7;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN Name=kdpD2 {ECO:0000313|EMBL:CAJ95687.1};
GN OrderedLocusNames=H16_B0895 {ECO:0000313|EMBL:CAJ95687.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ95687.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ95687.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; AM260480; CAJ95687.1; -; Genomic_DNA.
DR RefSeq; WP_011616870.1; NZ_CP039288.1.
DR AlphaFoldDB; Q0K2T7; -.
DR STRING; 381666.H16_B0895; -.
DR GeneID; 57646786; -.
DR KEGG; reh:H16_B0895; -.
DR eggNOG; COG2205; Bacteria.
DR HOGENOM; CLU_000445_113_0_4; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000008210; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:CAJ95687.1};
KW Ion transport {ECO:0000313|EMBL:CAJ95687.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CAJ95687.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAJ95687.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:CAJ95687.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 458..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 516..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 716..937
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 948 AA; 102854 MW; 3C417DBBFC746EF1 CRC64;
MPDAELREAG SRPDPDALLQ MVQEEGARAS RGKLRVYFGA SAGVGKTFAM LTAARTASAR
GTDAVIGIVE THGRAETEAL IAGIERLPMK DVPYRERVLQ EFDLDAALVR RPALVLVDEL
AHSNAPGSRH PKRWQDIQEL QAAGIDVWTT VNVQHLDSLN EAVGGITGIR VWETVPDVVF
DSADEVVLVD LPADELLRRL KEGKVYLPEQ ARHAARNFFR KGNLIALREL ALRRTADRVD
SDVRAWRQSE AVQGVWRTRE AVLACIGSGD DAEQVVRSAR RLAGQLDCDW HVVTIATPRL
APPSDFAKTR LQTAMRLAEE LGARTETLAG NDMVQAIVGY VRRHNLTKVV IGRAPADWRR
GGASVAERAR SLLGLALTPF VNAPAWLFGR RSFADALALG CPEIDIIRVA ADTTRVDLRP
RHGTEAPDAP APGDGATRKD YLWAAAWCAG ATALSALAFP WFDVVNIAML FLAAVVGVAL
RHGRGPAALA SVLAVAAFDF FFVPPRLSFA VSDVQYLLTF LVLLSVGLVI GQLTAGLREQ
AQVAVQREND ARTLYELARE LSAALVPNQI VSIASRFLRA AFDANSAFFL VSAEGRLLPP
VSDVEQHDTG ARTDSIDRVL AEWVFDHGQP AGTGTHTLPG STVLYLPLKA PMQTRGVLAV
EPAVSRAFAQ PALRRQVDVF CTLIAIAIER LHYVEVAQLA LLSMESERLR SSLLAAVSHD
LRTPLTSLIG MAETMQRSDP GLAPSLAETV AAMLEQARRM RTMVVNLLDM AKLQGREVRM
SKEWQSVEEL VGASLAAMRE ALEHHRVVVV DLSRVPLVEC DAVLIERVLC NLLENAAKYT
PAGTEIRLSA APVDDEIRIA VEDDGPGVPK GKERQIFEKF TRGERESATA GVGLGLAVCE
AIVQAHGGRI WVEPAQRPDR PGGQAGARFL VALPRGNPPA VEPEQTDA
//
