ID   Q0KC53_CUPNH            Unreviewed;      1304 AA.
AC   Q0KC53;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 119.
DE   SubName: Full=ATP-dependent transcriptional regulator containing adenylate cyclase related domains {ECO:0000313|EMBL:CAJ92418.1};
GN   OrderedLocusNames=H16_A1278 {ECO:0000313|EMBL:CAJ92418.1};
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ92418.1, ECO:0000313|Proteomes:UP000008210};
RN   [1] {ECO:0000313|EMBL:CAJ92418.1, ECO:0000313|Proteomes:UP000008210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC   337 {ECO:0000313|Proteomes:UP000008210};
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000256|ARBA:ARBA00005820}.
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DR   EMBL; AM260479; CAJ92418.1; -; Genomic_DNA.
DR   RefSeq; WP_011614979.1; NZ_CP039287.1.
DR   STRING; 381666.H16_A1278; -.
DR   GeneID; 57643375; -.
DR   KEGG; reh:H16_A1278; -.
DR   PATRIC; fig|381666.6.peg.1665; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3629; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   HOGENOM; CLU_006294_0_0_4; -.
DR   OrthoDB; 135231at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00028; TPR; 6.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          19..94
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|SMART:SM00862"
FT   DOMAIN          99..238
FT                   /note="Bacterial transcriptional activator"
FT                   /evidence="ECO:0000259|SMART:SM01043"
FT   REPEAT          1120..1153
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1304 AA;  139671 MW;  3A5F13506D866A86 CRC64;
     MARARLDLFG GFQLSSADGT PISLSARKAR AVLAYLALAQ GRAQPRDKLA ALCWAESNTE
     QARSSLRQAL SAARRALEEA GQHVVLAEGD SVTLGEIGVD VCEFEQCARE ATPASLERAA
     ALYRGDLLEG FHAAAPAFDH WLAIERERLR GVALAVMARL LAHHEQAGET ERAIATATRL
     LALDPLQEDV HRTLIRLYER QGRQALALKQ YRLCRAALQR ELGVSPEPET EALYQAMLRA
     RREPVAGMAA AGDDGAAVPP ACAVMAAEPQ LRHAVVLVAS LDDSSAGLEP EPLHDALARW
     RQHARALASA CGGHITDEIG TRLTIVFGVP VAHGNDAERA LHTAGALHAG LARLAESANA
     RLLARVGLAS GQVLAACRES GMTLTGGPVS VALQAMERAE PGATMVSNRV YQALPGRLEA
     DCVAHAVLPG VAEPIPLWRV RRFLGVEQAP AQHAFVGRQA ELAQLAGVAD SCLRSGHGRV
     VLIRGEAGIG KSRLADRFVA LAREHGLEAH RALVLDFGAG SGGDPLRMLA RNLLGVAPRT
     GADGAAAEVA TGAAIEQALA AWQLGEDELG FARDMFEQPQ SQEQAAALAA MDAASRQRGA
     QRLMVTLATR RSVVRTQLIV VEDVHWAERT VLDCLAQLAA ATRSHALILV LTVRPEHDPL
     DAAWRATSQG ASLTTIDLGP LDDAEAHELA ACHRQVDPAV AATCIRRAEG NPLFLDQLLR
     GAEAGADELP GTLQSIVLAR MDRFSTADRQ ALQAAAVLGQ RFGPAALRHL LEDPAYACER
     LVQEAMARPE GEDYLFMHAL IHEAVYASLL KSRRQNLHRR AAAWYEGRNP ALAAEHLDAA
     GDPGAPEAYA AAARHEAAHF RGERALRLVE RAQRLDSGDA CRHTLACLHG ELALDLGLPT
     QSLQAFRQAQ LLASDAAQRA RVWLGTAAAL RLLDRYDEAL AALREAEQAA AALGQPERLA
     EIESLRGNLY FPKGDMEECL AAHQRALSHA RAAGSVLGEA RALGGLGDAY YQQGRMLTAH
     AHFVRCVELA RAHGFIRIEC ANLPMVGAVE LFRNELAAAQ ASCEEGLRLA RRISDARSEM
     LAYDVMASTA QLAGDWPGAE AHARLALALT RRLGARRFEA EVLARLGLAI GALGQVEEAE
     SVLDEALQLS HASGVRYSGP TVLAFLARTT RDPDKQLDAL RQGEAILAQG CVSHCHVDLL
     EAAIDVSLAA RRWQEAERYL AALQDYMQHE PFPWGDFLIR RGRALICAGR EQGAGTTPPL
     FARLRLLRDE AHAAGLNESL GAIDAALERL AATSRIESDA SGRS
//