ID Q0NPN0_COWPX Unreviewed; 355 AA.
AC Q0NPN0;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Soluble interferon alpha/beta receptor OPG204 {ECO:0000256|ARBA:ARBA00041012};
GN ORFNames=CPXV_GER91_3_200 {ECO:0000313|EMBL:ABD97547.1};
OS Cowpox virus (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10243 {ECO:0000313|EMBL:ABD97547.1, ECO:0000313|Proteomes:UP000136830};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|EMBL:ABD97547.1, ECO:0000313|Proteomes:UP000136830}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Germany 91-3 {ECO:0000313|EMBL:ABD97547.1};
RX PubMed=16873609; DOI=10.1126/science.1125134;
RA Esposito J.J., Sammons S.A., Frace A.M., Osborne J.D., Olsen-Rasmussen M.,
RA Zhang M., Govil D., Damon I.K., Kline R., Laker M., Li Y., Smith G.L.,
RA Meyer H., LeDuc J.W., Wohlhueter R.M.;
RT "Genome sequence diversity and clues to the evolution of variola (smallpox)
RT virus.";
RL Science 313:807-812(2006).
CC -!- SUBUNIT: Interacts with host IFNA1. {ECO:0000256|ARBA:ARBA00038761}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; DQ437593; ABD97547.1; -; Genomic_DNA.
DR Proteomes; UP000136830; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR013151; Immunoglobulin.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF44; X-LINKED INTERLEUKIN-1 RECEPTOR ACCESSORY PROTEIN-LIKE 2; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 3: Inferred from homology;
KW Early protein {ECO:0000256|ARBA:ARBA00022518};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00022632};
KW Inhibition of host interferon signaling pathway by virus
KW {ECO:0000256|ARBA:ARBA00022830};
KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00022830};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280}.
FT DOMAIN 159..241
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 250..349
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 355 AA; 41137 MW; 612C6E05DE0EC3B5 CRC64;
MKMTMKMMVH IYFVSLSLSL LLFHSYAIDI ENEITEFFNK MKDTLPAKDS KWLNPACMFG
GTINDMAALG EPFSAKCPPI EDSLLSHRYK DYVVKWERLE KNRRRQVSNK RVKHGDLWIA
NYTSKFSNRR YLCTVTTKNG DCVQGIVRSH IRKPPSCIPK TYELGTHDKY GIDLYCGILY
AKHYNNITWY KDNKEINIDD IKYSQTGKEL IIHNPELEDS GRYDCYVHYD DVRIKNDIVV
SRCKILTVIP SQDHRFKLIL DPKINVTIGE PANITCTAVS TSLLIDDVLI EWENPSGWLI
GFDFDVYSVL TSRGGITEAT LYFENVTEEY IGNTYKCRGH NYYFEKTLTT TVVLE
//
