ID Q0PKX7_DANRE Unreviewed; 268 AA.
AC Q0PKX7; A4FVG4;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 137.
DE SubName: Full=Fas ligand {ECO:0000313|EMBL:AAI33843.1, ECO:0000313|EMBL:ABG91565.1, ECO:0000313|Ensembl:ENSDARP00000136343};
DE SubName: Full=Tumor necrosis factor ligand superfamily member 6 {ECO:0000313|RefSeq:NP_001036166.1};
GN Name=faslg {ECO:0000313|EMBL:AAI33843.1,
GN ECO:0000313|Ensembl:ENSDARP00000136343,
GN ECO:0000313|ZFIN:ZDB-GENE-070410-16};
GN Synonyms=fasl {ECO:0000313|EMBL:ABG91565.1,
GN ECO:0000313|RefSeq:NP_001036166.1}, zgc:162027
GN {ECO:0000313|RefSeq:NP_001036166.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI33843.1};
RN [1] {ECO:0000313|EMBL:ABG91565.1, ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tubingen {ECO:0000313|EMBL:ABG91565.1};
RX PubMed=16888647; DOI=10.1038/sj.cdd.4402015;
RA Eimon P.M., Kratz E., Varfolomeev E., Hymowitz S.G., Stern H., Zha J.,
RA Ashkenazi A.;
RT "Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.";
RL Cell Death Differ. 13:1619-1630(2006).
RN [2] {ECO:0000313|EMBL:AAI33843.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAI33843.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19598108;
RA Poulton L.D., Nolan K.F., Anastasaki C., Waldmann H., Patton E.E.;
RT "A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in
RT early embryonic zebrafish development.";
RL Int. J. Dev. Biol. 54:815-825(2010).
RN [4] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21527275;
RA Wiens G.D., Glenney G.W.;
RT "Origin and evolution of TNF and TNF receptor superfamilies.";
RL Dev. Comp. Immunol. 35:1324-1335(2011).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000136343, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136343};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24349563;
RA Liu C., Xu H., Lam S.H., Gong Z.;
RT "Selection of reliable biomarkers from PCR array analyses using relative
RT distance computational model: methodology and proof-of-concept study.";
RL PLoS ONE 8:e83954-e83954(2013).
RN [7] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25071022;
RA Ferrari L., Pistocchi A., Libera L., Boari N., Mortini P., Bellipanni G.,
RA Giordano A., Cotelli F., Riva P.;
RT "FAS/FASL are dysregulated in chordoma and their loss-of-function impairs
RT zebrafish notochord formation.";
RL Oncotarget 5:5712-5724(2014).
RN [8] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=25792259;
RA Biswas G., Kinoshita S., Kono T., Hikima J., Sakai M.;
RT "Evolutionary evidence of tumor necrosis factor super family members in the
RT Japanese pufferfish (Takifugu rubripes): Comprehensive genomic
RT identification and expression analysis.";
RL Mar. Genomics 22:25-36(2015).
RN [9] {ECO:0000313|Ensembl:ENSDARP00000136343}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136343};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [10] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27288846;
RA Wang Q., Liu S., Hu D., Wang Z., Wang L., Wu T., Wu Z., Mohan C., Peng A.;
RT "Identification of apoptosis and macrophage migration events in paraquat-
RT induced oxidative stress using a zebrafish model.";
RL Life Sci. 157:116-124(2016).
RN [11] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27356472;
RA Hu P., Liu M., Liu Y., Wang J., Zhang D., Niu H., Jiang S., Wang J.,
RA Zhang D., Han B., Xu Q., Chen L.;
RT "Transcriptome comparison reveals a genetic network regulating the lower
RT temperature limit in fish.";
RL Sci. Rep. 6:28952-28952(2016).
RN [12] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29874755;
RA Liu J., Sun L., Zhang H., Shi M., Dahlgren R.A., Wang X., Wang H.;
RT "Response mechanisms to joint exposure of triclosan and its chlorinated
RT derivatives on zebrafish (Danio rerio) behavior.";
RL Chemosphere 193:820-832(2018).
RN [13] {ECO:0000313|RefSeq:NP_001036166.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29883909;
RA Deng S., Jia P.P., Zhang J.H., Junaid M., Niu A., Ma Y.B., Fu A., Pei D.S.;
RT "Transcriptomic response and perturbation of toxicity pathways in zebrafish
RT larvae after exposure to graphene quantum dots (GQDs).";
RL J. Hazard. Mater. 357:146-158(2018).
RN [14] {ECO:0000313|RefSeq:NP_001036166.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; CABZ01015863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC133842; AAI33843.1; -; mRNA.
DR EMBL; DQ812115; ABG91565.1; -; mRNA.
DR RefSeq; NP_001036166.1; NM_001042701.2.
DR STRING; 7955.ENSDARP00000136343; -.
DR PaxDb; 7955-ENSDARP00000074711; -.
DR Ensembl; ENSDART00000171991.2; ENSDARP00000136343.1; ENSDARG00000098913.2.
DR GeneID; 735295; -.
DR KEGG; dre:735295; -.
DR AGR; ZFIN:ZDB-GENE-070410-16; -.
DR CTD; 356; -.
DR ZFIN; ZDB-GENE-070410-16; faslg.
DR eggNOG; ENOG502S09I; Eukaryota.
DR HOGENOM; CLU_070352_2_0_1; -.
DR OMA; THIVYKK; -.
DR OrthoDB; 5347330at2759; -.
DR TreeFam; TF332169; -.
DR Reactome; R-DRE-3371378; Regulation by c-FLIP.
DR Reactome; R-DRE-5218900; CASP8 activity is inhibited.
DR Reactome; R-DRE-69416; Dimerization of procaspase-8.
DR Reactome; R-DRE-75157; FasL/ CD95L signaling.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000098913; Expressed in intestine and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030903; P:notochord development; IMP:ZFIN.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IBA:GO_Central.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF33; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 6; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 129..267
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 268 AA; 30203 MW; E0407C80FD97C23E CRC64;
MSANFGHSSQ PVFMVDSAGN HPKQHRYYHQ QVPRHPEPPL VPCWTFPPAR VEMKKKGWGG
MNAGLAWVVT LILLLVFAAL GLGAYQILRL QTKLEQLTQE LPTIMQSSAP QKQVGLNPAE
LKKNKYKSAA HLIGYAEQSK SPGLLKWISN HGDAFTDGVK YTDGGLQVNE TGLYFVYSRV
EFLSHTCKTF DSLAHKISLK RNGNSQIIME DNIEGFCMTS KNHPWVTGSQ LGSLQQLREL
DWLFVNVSRP HLLSKNFHSN YFGLFKIH
//
