ID   Q0QVQ3_BCHK4            Unreviewed;       598 AA.
AC   Q0QVQ3;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   SubName: Full=Helicase {ECO:0000313|EMBL:ABB77055.1};
DE   Flags: Fragment;
OS   Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae;
OC   Betacoronavirus; Merbecovirus.
OX   NCBI_TaxID=694007 {ECO:0000313|EMBL:ABB77055.1};
OH   NCBI_TaxID=258959; Tylonycteris pachypus (Lesser bamboo bat) (Vespertilio pachypus).
RN   [1] {ECO:0000313|EMBL:ABB77055.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HKU4-4 {ECO:0000313|EMBL:ABB77055.1};
RA   Woo P.C.Y., Lau S.K.P., Li K.S.M., Poon R.W.S., Wong B.H.L., Tsoi H.W.,
RA   Yuen K.Y.;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ABB77055.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=HKU4-4 {ECO:0000313|EMBL:ABB77055.1};
RX   PubMed=16647731; DOI=10.1016/j.virol.2006.02.041;
RA   Woo P.C., Lau S.K., Li K.S., Poon R.W., Wong B.H., Tsoi H.W., Yip B.C.,
RA   Huang Y., Chan K.H., Yuen K.Y.;
RT   "Molecular diversity of coronaviruses in bats.";
RL   Virology 351:180-187(2006).
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DR   EMBL; DQ249241; ABB77055.1; -; Genomic_RNA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd21409; 1B_cv_Nsp13-like; 1.
DR   CDD; cd21722; betaCoV_Nsp13-helicase; 1.
DR   CDD; cd21689; stalk_CoV_Nsp13-like; 1.
DR   CDD; cd21401; ZBD_cv_Nsp13-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027351; (+)RNA_virus_helicase_core_dom.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR044343; NSP13_1B_dom_CoV.
DR   InterPro; IPR048673; NSP13_stalk_CoV.
DR   InterPro; IPR048672; NSP13_ZBD_CoV.
DR   InterPro; IPR027352; NSP13_ZBD_CoV-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR43788:SF8; HELICASE WITH ZINC FINGER 2; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF13604; AAA_30; 1.
DR   Pfam; PF20631; CoV_NSP13_1B; 1.
DR   Pfam; PF20633; CoV_NSP13_stalk; 1.
DR   Pfam; PF20632; CoV_NSP13_ZBD; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51653; CV_ZBD; 1.
DR   PROSITE; PS51657; PSRV_HELICASE; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000313|EMBL:ABB77055.1};
KW   Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Hydrolase {ECO:0000313|EMBL:ABB77055.1};
KW   Membrane {ECO:0000256|ARBA:ARBA00022870};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00986};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00986}.
FT   DOMAIN          1..84
FT                   /note="CV ZBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51653"
FT   DOMAIN          257..598
FT                   /note="(+)RNA virus helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51657"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ABB77055.1"
FT   NON_TER         598
FT                   /evidence="ECO:0000313|EMBL:ABB77055.1"
SQ   SEQUENCE   598 AA;  66004 MW;  4454FDE5D2C17696 CRC64;
     AVGSCVVCHS QTSLRCGTCI RRPFLCCKCC YDHVIATPHK MVLSVSPYVC NAPGCDVSDV
     TKLYLGGMSY YCNDHRPVCS FPLCANGLVF GLYKNMCTGS SSIMEFNRLA TCDWSDSGDY
     TLANTTTEPL KLFAAETLRA TEEASKQSYA IATIKEIVGE RELILVWEVG KSKPPLNRNY
     VFTGYHLTKN SKVQLGEYVF ERIDYSDAVS YKSSTTYKLA VGDIFVLTSH SVATLSAPTI
     VNQERYLKIT GIYPTITVPE EFANHVVNFQ KAGFSKYVTV QGPPGTGKSH FAIGLAIYYP
     TARIVYTACS HAAVDALCEK AFKYLNIAKC SRIIPAKARV ECYDRFKVND TNSQYLFSTV
     NALPEISVDI LVVDEVSMCT NYDLSIINSR VKAKHIVYVG DPAQLPAPRT LLIRGTLEPE
     NFNSVTRLMC NLGPDIFLSV CYRCPKEIVS TVSALVYNNK LSAKKDASGQ CFKILFKGSV
     THDASSAINR PQLNFVKTFI AANPNWSKAV FISPYNSQNA VARSMLGLTT QTVDSSQGSE
     YPYVIFCQTA DTAHANNLNR FNVAVTRAQK GILCVMTSQV LFDSLEFAEL SLNNYKLQ
//