ID Q0UTD8_PHANO Unreviewed; 1210 AA.
AC Q0UTD8;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=Ras guanine-nucleotide exchange protein Cdc25p {ECO:0008006|Google:ProtNLM};
GN ORFNames=SNOG_04976 {ECO:0000313|EMBL:EAT87367.1};
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614 {ECO:0000313|EMBL:EAT87367.1, ECO:0000313|Proteomes:UP000001055};
RN [1] {ECO:0000313|Proteomes:UP000001055}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173
RC {ECO:0000313|Proteomes:UP000001055};
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G., Solomon P.S., Tan K.C., Schoch C.L., Spatafora J.W.,
RA Crous P.W., Kodira C., Birren B.W., Galagan J.E., Torriani S.F.,
RA McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
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DR EMBL; CH445331; EAT87367.1; -; Genomic_DNA.
DR RefSeq; XP_001795388.1; XM_001795336.1.
DR AlphaFoldDB; Q0UTD8; -.
DR STRING; 321614.Q0UTD8; -.
DR EnsemblFungi; SNOT_04976; SNOT_04976; SNOG_04976.
DR GeneID; 5972263; -.
DR KEGG; pno:SNOG_04976; -.
DR VEuPathDB; FungiDB:JI435_049760; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002116_1_0_1; -.
DR InParanoid; Q0UTD8; -.
DR OMA; EEVWERD; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001055};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 79..149
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 737..858
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 920..1165
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 30..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..604
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 133848 MW; 9570AF34FAD6C7CF CRC64;
MADWAFDQDG MDKHSSALVA PLNIQKSPKR SRVGIFAHSR QSSRGARSVT SQSQSQISPP
LTPKTSNEVM VQQTPPQPVF HNYLRAFYHY EPTSTVCSST DESSITVAIK QGDIILVHSV
HPNGWADGTL LASGARGWLP TNYCEPYDHP AVRNLLNALT HLWDLVRDGE NGDLIAFMRQ
DYVRGMISGI RFFLERTGCL SRDSRLIVAH IGLRRMRKGL LGDLSTLVKT AKKLQETLQA
NEAPVPVYEY MDELVLKSFK LVTRAVRFLD IWATDAVSLS SFELGDVSAE RPLTPPSDAA
VQPLSSLDQQ HAPICIANDG DDHVAQRSFC LPEDVASAQP LRNPNRLSVA FSLPSESESL
PPQSPTLVSH FPSQTKRLSV THRLSYTGKS QSTRTGSLAS DKLVASQDAF LGFIGSFIGL
HLQSRSSEEL AYITQQSVVA CQQLLAVVDE VWERDARRSK DLEEARDTMY ARLTELVQAT
KDMFSVTDTE MNEALVAPES GKQLVAAATS CVRSAGECAA KARVVIERIG DFEFEAVGLG
LSDAIFQQLP VTNESEQEKS ELPRPMETVL ETDKPLPAPP SEERHLPPPL VISESKPLPE
VPQPSPLDNQ RLSLQPTPAP IIVESPIAMS FRSSRSSITP LNTLPMPNLQ PAPVELLDSP
MSTTQGPFPN QARADSVNVS VTDTNSTFPF QHARHRERCV THFNQSHYAR QFSCKEPELN
RPFVSSFGSS SELRSLASED LAAGEEHMLE TTFLTTYETT PDAVFVTTFY LTFRLFTTPV
ELAQCLIDRF DYIGDSQSIG VPVRLRVYNV FKGWLESHWA SDSDSAALEL ILSFATGKLR
ESMPAAGRRL ADLTSKVNEV RAGAPLVPRL VSSISKAGAS YTSFTPADSN VPSSNVSKGQ
LNALRASKEG KAQCSILDFD PLELARQFTI IESRLFCSIQ SEELLALEWT KKSDSKAVNV
KAMSTLSTDL ANLVADTILH LEDAKKRAAI IKQWVKIAAK CLELNNYDSL MAIICSLNSS
MVMRLKRTWE LVSTKTKTRL EELKAITDVG RNYAVLRQRL QNHVAPCIPF VGIYLTDLTF
IDVGNGTTRQ LPGEAGEDSV SVINFDKHMK TAKIIGQLQS FQVPYQLAAV PEMQDWMEAQ
IQRVRSSDQA NVQSYYRRSL LLEPRDPQHS VRGSPSIDQG TFTAENRTTS REKFEFLNFN
FGSTSNLKSS
//
