ID Q0V9U3_XENTR Unreviewed; 571 AA.
AC Q0V9U3; F6X7N7;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Cyclin-K {ECO:0000313|EMBL:AAI21395.1, ECO:0000313|Ensembl:ENSXETP00000024974};
GN Name=ccnk {ECO:0000313|EMBL:AAI21395.1,
GN ECO:0000313|Ensembl:ENSXETP00000024974,
GN ECO:0000313|RefSeq:NP_001072323.1,
GN ECO:0000313|Xenbase:XB-GENE-478709};
GN Synonyms=cpr4 {ECO:0000313|RefSeq:NP_001072323.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI21395.1};
RN [1] {ECO:0000313|RefSeq:NP_001072323.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI21395.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI21395.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000024974}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000024974};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000024974}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001072323.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; BC121394; AAI21395.1; -; mRNA.
DR RefSeq; NP_001072323.1; NM_001078855.1.
DR STRING; 8364.ENSXETP00000024974; -.
DR Ensembl; ENSXETT00000024974; ENSXETP00000024974; ENSXETG00000011438.
DR GeneID; 779776; -.
DR KEGG; xtr:779776; -.
DR AGR; Xenbase:XB-GENE-478709; -.
DR CTD; 8812; -.
DR Xenbase; XB-GENE-478709; ccnk.
DR eggNOG; KOG0834; Eukaryota.
DR HOGENOM; CLU_022000_0_2_1; -.
DR OMA; FVIACCR; -.
DR OrthoDB; 4848076at2759; -.
DR TreeFam; TF101010; -.
DR Reactome; R-XTR-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR Reactome; R-XTR-674695; RNA Polymerase II Pre-transcription Events.
DR Reactome; R-XTR-6796648; TP53 Regulates Transcription of DNA Repair Genes.
DR Reactome; R-XTR-6807505; RNA polymerase II transcribes snRNA genes.
DR Reactome; R-XTR-75955; RNA Polymerase II Transcription Elongation.
DR Proteomes; UP000008143; Chromosome 8.
DR Bgee; ENSXETG00000011438; Expressed in gastrula and 12 other cell types or tissues.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20530; CYCLIN_CCNK_rpt1; 1.
DR CDD; cd20531; CYCLIN_CCNK_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF51; CYCLIN-K; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR Pfam; PF21797; CycT2-like_C; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 2: Evidence at transcript level;
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 55..149
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 158..288
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 162..256
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 262..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..561
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 571 AA; 63424 MW; DE7C8D8106B18614 CRC64;
MKENKENSSP STAPASLDHA KPCWYWDKKD LAHTPSQLEG LDPATEARYR REGARFIFDV
GTRLGLHYDT LATGIIYFHR FYMFHSFKQF PRYVTGACCL FLAGKVEETP KKCKDIIKTA
RSLLNDVQFG QFGDDPKEEV MVLERILLQT IKFDLQVEHP YQFLLRYAKQ LKGDKNKIQK
LVQMAWTFVN DSLCTTLSLQ WEPEIIAVAV MYLAGRLCKF EIQEWTSKPL YRRWWEQFVQ
DVPVDVLEDI CHQILDLYSQ GKQQMPHHGA PQTSPQVQAQ IASVQPQQQT QNADLQTAPQ
KEQQQTTSQQ PKKPSPQSSP PKPVKRPLPT SPKDDSKVIE QPLPKLSKIE ISHPPLPPVL
PPPERKPLVP SIAVSEGDPA VALEPAEHTK IQIPPPAHPA PVHQPPPIPH RPPPPPPASY
ITGMSTTNSY MSGEGYQSLQ SMMKTEGPTY GSLPPTYGPP AHLPYHPHVF PPNPPPTVPP
PPPPSSFPPP NIPPPTPVYP PPPAYNPNFP PPRLPPTHTV PSHPPPGIAM PPTSYPPPAV
PPGGQPPVVP PPIPPPGMPP VAGLGRAAWM R
//
