ID Q0VM54_ALCBS Unreviewed; 282 AA.
AC Q0VM54;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=Lipopolysaccharide core heptose(I) kinase {ECO:0000256|PIRNR:PIRNR037318};
DE EC=2.7.1.- {ECO:0000256|PIRNR:PIRNR037318};
GN Name=waaP2 {ECO:0000313|EMBL:CAL17744.1};
GN OrderedLocusNames=ABO_2296 {ECO:0000313|EMBL:CAL17744.1};
OS Alcanivorax borkumensis (strain ATCC 700651 / DSM 11573 / NCIMB 13689 /
OS SK2).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Alcanivoracaceae; Alcanivorax.
OX NCBI_TaxID=393595 {ECO:0000313|EMBL:CAL17744.1, ECO:0000313|Proteomes:UP000008871};
RN [1] {ECO:0000313|EMBL:CAL17744.1, ECO:0000313|Proteomes:UP000008871}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700651 / DSM 11573 / NCIMB 13689 / SK2
RC {ECO:0000313|Proteomes:UP000008871};
RX PubMed=16878126; DOI=10.1038/nbt1232;
RA Schneiker S., Martins dos Santos V.A.P., Bartels D., Bekel T., Brecht M.,
RA Buhrmester J., Chernikova T.N., Denaro R., Ferrer M., Gertler C.,
RA Goesmann A., Golyshina O.V., Kaminski F., Khachane A.N., Lang S., Linke B.,
RA McHardy A.C., Meyer F., Nechitaylo T., Puehler A., Regenhardt D., Rupp O.,
RA Sabirova J.S., Selbitschka W., Yakimov M.M., Timmis K.N., Vorhoelter F.-J.,
RA Weidner S., Kaiser O., Golyshin P.N.;
RT "Genome sequence of the ubiquitous hydrocarbon-degrading marine bacterium
RT Alcanivorax borkumensis.";
RL Nat. Biotechnol. 24:997-1004(2006).
CC -!- FUNCTION: Kinase involved in the biosynthesis of the core
CC oligosaccharide region of lipopolysaccharide (LPS). Catalyzes the
CC phosphorylation of heptose I (HepI), the first heptose added to the
CC Kdo2-lipid A module. {ECO:0000256|PIRNR:PIRNR037318}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|PIRNR:PIRNR037318}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. KdkA/rfaP
CC family. {ECO:0000256|PIRNR:PIRNR037318}.
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DR EMBL; AM286690; CAL17744.1; -; Genomic_DNA.
DR RefSeq; WP_011589570.1; NC_008260.1.
DR AlphaFoldDB; Q0VM54; -.
DR STRING; 393595.ABO_2296; -.
DR KEGG; abo:ABO_2296; -.
DR eggNOG; COG0515; Bacteria.
DR HOGENOM; CLU_081267_0_0_6; -.
DR OrthoDB; 9782725at2; -.
DR UniPathway; UPA00958; -.
DR Proteomes; UP000008871; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR017172; Lsacc_core_hep_kinase_RfaP.
DR Pfam; PF06293; Kdo; 1.
DR PIRSF; PIRSF037318; RfaP; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRNR:PIRNR037318};
KW Kinase {ECO:0000256|PIRNR:PIRNR037318, ECO:0000313|EMBL:CAL17744.1};
KW Lipopolysaccharide biosynthesis {ECO:0000256|PIRNR:PIRNR037318};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR037318};
KW Reference proteome {ECO:0000313|Proteomes:UP000008871};
KW Transferase {ECO:0000256|PIRNR:PIRNR037318, ECO:0000313|EMBL:CAL17744.1}.
SQ SEQUENCE 282 AA; 32149 MW; 94D271473D3552AB CRC64;
MSKMLREDLA AAWAGKDPFE QAARQQGDIF REREGRRTLR FFHAGKGYFL KYHGGIGWRE
IFKNLAQGKL PVLGAMQEVR AIDAVRAAGL DTMTVAGYGC RGHNPSRQES FLVTDELADT
LSLEEVGESW LEAGEVPVGF KRELIRRVAA IARRMHDAGI NHRDFYLAHF LMPAPAVHAR
DETAPLFLID LHRSQVRGAV PQRWRVKDLG GLYFSTARYG MTRRDVLRFV REYSGLSLRD
VLTEKSALLA ASQREGEKIY RRYYEKKPQF PLQFNAHPGK DI
//
