ID Q0ZD40_POLSE Unreviewed; 124 AA.
AC Q0ZD40;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Pancreatic and duodenal homeobox {ECO:0000313|EMBL:ABF60828.1};
DE Flags: Fragment;
GN Name=Pdx1 {ECO:0000313|EMBL:ABF60828.1};
OS Polypterus senegalus (Senegal bichir).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Polypteriformes; Polypteridae; Polypterus.
OX NCBI_TaxID=55291 {ECO:0000313|EMBL:ABF60828.1};
RN [1] {ECO:0000313|EMBL:ABF60828.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16801555; DOI=10.1073/pnas.0600341103;
RA Mulley J.F., Chiu C.-H., Holland P.W.H.;
RT "Breakup of a homeobox cluster after genome duplication in teleosts.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:10369-10372(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR EMBL; DQ522897; ABF60828.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0ZD40; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF12; PANCREAS_DUODENUM HOMEOBOX PROTEIN 1; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 8..68
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 10..69
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 64..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABF60828.1"
SQ SEQUENCE 124 AA; 14511 MW; C972B14F72E7CFAA CRC64;
GSYMVEQEEN KRTRTAYTRA QLLELEKEFL FNKYISRPRR VELAVMLNLT ERHIKIWFQN
RRMKWKKEED KKRSKIDDPE QDSSISSGDL KDEACGQSLT HSRDLVTGNI ASSPQHNILK
GSSI
//
