ID Q12H32_POLSJ Unreviewed; 297 AA.
AC Q12H32;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=6-phosphogluconate dehydrogenase, NAD-binding protein {ECO:0000313|EMBL:ABE42160.1};
GN OrderedLocusNames=Bpro_0195 {ECO:0000313|EMBL:ABE42160.1};
OS Polaromonas sp. (strain JS666 / ATCC BAA-500).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Comamonadaceae; Polaromonas.
OX NCBI_TaxID=296591 {ECO:0000313|EMBL:ABE42160.1, ECO:0000313|Proteomes:UP000001983};
RN [1] {ECO:0000313|Proteomes:UP000001983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JS666 / ATCC BAA-500 {ECO:0000313|Proteomes:UP000001983};
RX PubMed=18723656; DOI=10.1128/AEM.00197-08;
RA Mattes T.E., Alexander A.K., Richardson P.M., Munk A.C., Han C.S.,
RA Stothard P., Coleman N.V.;
RT "The genome of Polaromonas sp. strain JS666: insights into the evolution of
RT a hydrocarbon- and xenobiotic-degrading bacterium, and features of
RT relevance to biotechnology.";
RL Appl. Environ. Microbiol. 74:6405-6416(2008).
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DR EMBL; CP000316; ABE42160.1; -; Genomic_DNA.
DR RefSeq; WP_011481169.1; NC_007948.1.
DR AlphaFoldDB; Q12H32; -.
DR STRING; 296591.Bpro_0195; -.
DR KEGG; pol:Bpro_0195; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_1_4; -.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000001983; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001983}.
FT DOMAIN 4..163
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 166..277
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 172
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 297 AA; 30740 MW; 71652D540860181A CRC64;
MKHIGMIGAS GLMGHGIARN LQAKGFDLSL TVHRNTERVA DLLAAGAKQV ASPAGLGDCD
AVIICVTGSP QVEQTLSGPD GVLSRALAGL IVIDTSTSEP ESTRRLAALC AERGVTLVDA
PLARTPVEAE LGRLNTMVGA EQAVFDKIRP VLAAYCENIF HVGGPGAGHV IKLLNNFIGQ
AICTATAEAF AVGALAGINP QKLVEVISAG AVNSGLFQAM AKTLNGDFTG LKFELDNARK
DLRYYTHLAE MVNVPSLVGE AVHQSLATAS ALGQGKKFVP ALVTAQEKLT GAKIAPQ
//
