ID Q14QI1_SPICI Unreviewed; 450 AA.
AC Q14QI1;
DT 22-AUG-2006, integrated into UniProtKB/TrEMBL.
DT 22-AUG-2006, sequence version 1.
DT 08-NOV-2023, entry version 88.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN ECO:0000313|EMBL:CAK98248.1};
GN ORFNames=HHA36_00005 {ECO:0000313|EMBL:QJU60992.1}, SPICI01B_001
GN {ECO:0000313|EMBL:CAK98248.1};
OS Spiroplasma citri.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales; Spiroplasmataceae;
OC Spiroplasma.
OX NCBI_TaxID=2133 {ECO:0000313|EMBL:CAK98248.1};
RN [1] {ECO:0000313|EMBL:CAK98248.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=GII3-3X {ECO:0000313|EMBL:CAK98248.1};
RA Carle P., Saillard C., Carrere N., Carrere S., Duret S., Eveillard S.,
RA Gaurivaud P., Gourgues G., Gouzy J., Salar P., Verdin E., Breton M.,
RA Blanchard A., Laigret F., Bove J.M., Renaudin J., Foissac X.;
RT "Partial chromosome sequence of Spiroplasma citri reveals extensive viral
RT invasion and important gene decay.";
RL Appl. Environ. Microbiol. 76:3420-3426(2010).
RN [2] {ECO:0000313|EMBL:QJU60992.1, ECO:0000313|Proteomes:UP000501133}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C5 {ECO:0000313|EMBL:QJU60992.1,
RC ECO:0000313|Proteomes:UP000501133};
RA Rattner R., Dang T., Mello A.F.S., Espindola A.S., Cardwell K.,
RA Fletcher J., Yokomi R., Vidalakis G.;
RT "Genome-wide analyses of Spiroplamsa citri strains and comparison with
RT other spiroplasmas.";
RL Submitted (MAY-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00377}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU004227}.
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DR EMBL; AM285302; CAK98248.1; -; Genomic_DNA.
DR EMBL; CP053304; QJU60992.1; -; Genomic_DNA.
DR AlphaFoldDB; Q14QI1; -.
DR Proteomes; UP000501133; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.300.180; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR038454; DnaA_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00377};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00377};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00377}.
FT DOMAIN 138..271
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 357..426
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
FT BINDING 146..153
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00377"
SQ SEQUENCE 450 AA; 51564 MW; E901FA54FF5A768B CRC64;
MNTKELWIEV KEILSRDESV SPEIYNYYIS DTNLYTVSDN NCLITTKSEI AIGVFEAGLN
EKIKNILKKL TGIQYNISFE LEKNINKQAS VISKIDTLTE NNNLAYYENY TFENFVRGDS
NHEAMQAALA VALDLGKKWN PLFIYGDSGL GKTHLLHAIE NKVNEIYKTN NRVKYLKADE
FGKIAMDILN QGHEIIEAFK TSYDIYDCLL IDDIQLLAKR NKTNELFFHI FNSYIEKNKQ
IVITSDKYPD DLGGFEARII SRFSYGLSIG LDSPDFETAL KILEQKLKHQ NNLGLFSEES
LEFIALNFNS DVRKLEGAIK RLLFLAVMNK KPNEIITLAD VEKAFKNAPL QNNEKITPKK
IKQIVADNYN ITIKAMMSKS RVSNVMQARQ LAMYFCRTLL DEPFTRIGTE FGGKDHTTVM
NSVKKVEAHI STNKEFKHLV NAIRRKIEGR
//
