ID Q16FJ1_AEDAE Unreviewed; 599 AA.
AC Q16FJ1;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=AAEL014740-PA {ECO:0000313|EMBL:EAT33006.1};
GN ORFNames=AAEL014740 {ECO:0000313|EMBL:EAT33006.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT33006.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT33006.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33006.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT33006.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33006.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT33006.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33006.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH478425; EAT33006.1; -; Genomic_DNA.
DR RefSeq; XP_001649472.1; XM_001649422.1.
DR AlphaFoldDB; Q16FJ1; -.
DR STRING; 7159.Q16FJ1; -.
DR PaxDb; 7159-AAEL014740-PA; -.
DR VEuPathDB; VectorBase:AAEL002343; -.
DR eggNOG; KOG3558; Eukaryota.
DR HOGENOM; CLU_001570_5_2_1; -.
DR OMA; PSWCKEP; -.
DR PhylomeDB; Q16FJ1; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF26; PROTEIN TRACHEALESS; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 72..125
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 162..219
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 333..388
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 534..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 599 AA; 67353 MW; 1A6ABDEDE35D1CC4 CRC64;
MFPFSSLQVE YSNFHRSSQI MSNALSMTNS GFPHSWIVSG QDFCPITYSS IQSHNSAVSN
NLATVEPGLI ELRKEKSRDA ARSRRGKENY EFYELAKMLP LPAAITSQLD KASIIRLTIS
YLKLKEFSEN GVPSWNKEPI GFQNYTSPQY FNEMFETHLG THILQSLDGF AVSTGVDGRF
LYISETVSIY LGLSQVEMTG SSIFDYIHKG DHAEVEQQLG VKKNSDYYSG YSDEPPEKTV
LKIVKDSKPL PGETYEGDDR AFCVRMKSTL TKRGCHFKSS GYRVILLLCH LRKKNNSTDE
HSEKQTVIGM VGIGIALPPP SLHEIKLESD MFVFRTSLDL TIIHCENRIS SFLDYTADEL
NGKSVYTLCH GQDAPKLKKS HSELIQKGQV LTPFYRILNK NSGYFWIQTC CTMVCQTKSM
SDQTVICVNY IITRPEKENL ILDISQMPNV NHNDYHIGSK SVAAAAAKRA AAAASMEYEM
EVKDKYGELA GSQSDAYLDG HVDHKELIDK SPHKTMGLGM FDKKESLDFK DKHMDREKGC
SNSKQQRLKA GSPMMNMSVN ENQGIDKKSS NGKKNISNRA SVIRVLNKTS SKKILQENH
//
