ID Q16I75_AEDAE Unreviewed; 1020 AA.
AC Q16I75;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=AAEL013770-PA {ECO:0000313|EMBL:EAT33965.1};
GN ORFNames=AAEL013770 {ECO:0000313|EMBL:EAT33965.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT33965.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT33965.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33965.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT33965.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33965.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT33965.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT33965.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH478102; EAT33965.1; -; Genomic_DNA.
DR RefSeq; XP_001663975.1; XM_001663925.1.
DR AlphaFoldDB; Q16I75; -.
DR PaxDb; 7159-AAEL013770-PA; -.
DR VEuPathDB; VectorBase:AAEL013770; -.
DR eggNOG; KOG2461; Eukaryota.
DR HOGENOM; CLU_007033_0_1_1; -.
DR OMA; SINCTAY; -.
DR PhylomeDB; Q16I75; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd19187; PR-SET_PRDM1; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 5.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR044413; PRDM1_PR-SET.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR16515; PR DOMAIN ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR16515:SF26; PR DOMAIN ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00317; SET; 1.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 3.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 55..173
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 698..725
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 726..753
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 754..781
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 782..809
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 262..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..573
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1020 AA; 113813 MW; BF759D6B4D768EDF CRC64;
MAGTQPPRSV TPTVQQDYDV TRMREEDFER LAVYIVPDVP CEKGIPSRAD KTLPRSLTLK
PSLVLSTPTA TTEGVWSTGV IPRGTRFGPF EGVRTPSHPS DKQLWRYFWR IFKDSDFYYL
DGSDPAQSNW MRYVASAYSF SVMNLVACQH QEHIYFYTIR DIMPNEELMV WYCRDFAKRL
GYDIDPERAT YSICREETLK KTYGAIAKAP VPAEVAYNHV KHVMGLGMYM PAIRNAPTPS
PSPPAAVPST TTVVVPSKHQ MHQTVLREPR TAVEHHRDRS PVRLIIREQS PLRESAKEVD
ANSPISHNGK EAHYEHQLTP NDGSVRSDEG YHSNGYHEDA FTPPEDSSDS ESEHNYVLDC
SKKAIEPKET SVSQKAEICD KNEYRKVKMK MPLKYEFKNN KNFKSPSDKE DIVEEEEVVT
TREVTPATST VIVVDTTPET TIVPLTKTYY EAETSTSPAT YIRYSPPSSS ILETILTGSR
PQVDDPHRRQ PNATPPPTSP TEMAYSYKKS HRYGTACSPD SSSQNAEREI RESEPQILQD
TKIISIDHRE SQSPTLIYSS EHRPQSSHSP GPYEPSPHNY AIYPSPNGTV INNASSSTYS
PPLNGGHYER LTTHTIQSPH GFVQLQAKGQ LPLGHPLMQP LPPLTHMSPG RCSPPSSLSP
DGGSYSRSGS PMSPGSPGSR GYRSLPYPLR KRDGKMHYEC NVCSKTFGQL SNLKVHLRTH
SGERPFKCNV CTKSFTQLAH LQKHHLVHTG EKPHQCDICK KRFSSTSNLK THLRLHSGQK
PYACDLCPQK FTQFVHLKLH KRLHTNDRPY VCQGCDKKYI SASGLRTHWK TTSCKPNNLE
EELALAAAAT SECIDKDQPD SNDHREYYEL QNHPPSPVAP HQLRHVVVGH GSPPTLLGMS
PQHPGHLIQV HPGSDAIIQK VGKHPSSGNS PSSTTTTNNN NPTMVNGNVH YLGGPLPPQG
PLPHLQHHPH HHPASHQHQP PQISVMGHHG GGPAPPNSTE PPTSRPSVIE SSQPMIIECT
//
