ID Q16LJ3_AEDAE Unreviewed; 1002 AA.
AC Q16LJ3;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=AAEL012631-PA {ECO:0000313|EMBL:EAT35186.1};
GN ORFNames=AAEL012631 {ECO:0000313|EMBL:EAT35186.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT35186.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT35186.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35186.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT35186.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35186.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT35186.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35186.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; CH477904; EAT35186.1; -; Genomic_DNA.
DR RefSeq; XP_001662758.1; XM_001662708.1.
DR AlphaFoldDB; Q16LJ3; -.
DR STRING; 7159.Q16LJ3; -.
DR PaxDb; 7159-AAEL012631-PA; -.
DR VEuPathDB; VectorBase:AAEL025570; -.
DR eggNOG; KOG0164; Eukaryota.
DR HOGENOM; CLU_000192_7_7_1; -.
DR OMA; YMILRKY; -.
DR PhylomeDB; Q16LJ3; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF713; UNCONVENTIONAL MYOSIN ID; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 1..683
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 799..996
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 560..582
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 93..100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1002 AA; 116205 MW; 6BE465CA652DE195 CRC64;
MQGQAAKYVG RVLSVLNVII IAQFQAGKIY TYIGEVCISM NPYREMNIYG PEQVSRYKGR
ELFENMPHIF AIADAAYRVH KQRNQDTCIM ISGESGAGKT EASKIIMKYI AAVTNQGQQN
DIERVKNVLI QSNAILECFG NAKTNRNDNS SRFGKYMDIE FDYKGDPMGG IITNYLLEKS
RVIQQHPGER NFHCFYQLLR GASDAELRQY QLTRDPAQFH YTNQGSVEVL SEKLDYRVTT
AGLKALGFSG DELTMVWRIV AAVLHLGNIN FKTQDDQIQI ANRKTLSTAA QLLHVTEEEM
QRSLTERVIA ARGEIMTKTH DIEQAEFGRD ALAKAVYDRL FTWIIQRINK AIVVPGGNTQ
KRYNRVIGVL DIYGFEIFDQ NSFEQFCINY CNEKLQQLFI ELVLKQEQEE YRREGIKWTN
VDYFNNQIIC ELVEQPHKGV ISIMDEACLN VGKITDEMLL DAMDKKLSHH PHYSSRQLKP
MDKELKHRQD FRITHYAGDV IYCIYGFIEK NRDTLFQDFK RLLYHSKDNL ITSMWPEGAQ
DISKTTKRPL TAGTLFQRSM TELVATLLKK EPFYVRCIKP NDIKSASVFD DVRVEHQVRY
LGLLENVRVR RAGFVHRQRY DKFLLRYKMI SQYTWPNFRG GSERDGVKVL ITEKNFSHDV
EFGKTKIFLR SPQTLFSLEK QRNDMIPHIV TLLQKQVRGW ICRQQYKKMK AAIVIMRHYR
KYKLKSYVQE LAMRFRNARQ MRDYGKGIQW PQPPLVGREA EKQLRMLFSR WRAATILRKY
PREEWPQLRL QIIAASAFRK RRKFWGQDRR WLGNYLSITA ENSNYSSYNA SINNIKNTDN
FRVVLFSAFV KKFNKCNKSA DRAIIVTDGA IYKLDGPRNK FRNMKRTVAI KEITSISVSP
GRDQLVVFHS HHNNDLVIAL QGEQHPLKED RIGEIVAHVC KRYFELCNQD LPVTVSPTFQ
LRLGNKMRTL SVEAVAGVET PAFEHSGAVI VFKVPSSYGS AI
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