ID Q16MV8_AEDAE Unreviewed; 792 AA.
AC Q16MV8;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=AAEL012178-PA {ECO:0000313|EMBL:EAT35686.1};
GN ORFNames=AAEL012178 {ECO:0000313|EMBL:EAT35686.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT35686.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT35686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35686.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT35686.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35686.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT35686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT35686.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH477847; EAT35686.1; -; Genomic_DNA.
DR RefSeq; XP_001655921.1; XM_001655871.1.
DR AlphaFoldDB; Q16MV8; -.
DR STRING; 7159.Q16MV8; -.
DR PaxDb; 7159-AAEL012178-PA; -.
DR GeneID; 5575930; -.
DR KEGG; aag:5575930; -.
DR VEuPathDB; VectorBase:AAEL012178; -.
DR eggNOG; KOG2177; Eukaryota.
DR HOGENOM; CLU_008645_4_0_1; -.
DR OMA; GRCDTHA; -.
DR OrthoDB; 2901369at2759; -.
DR PhylomeDB; Q16MV8; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19757; Bbox1; 1.
DR CDD; cd14954; NHL_TRIM71_like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 3.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR PANTHER; PTHR24104:SF58; PROTEIN WECH; 1.
DR Pfam; PF01436; NHL; 5.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 2.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS51125; NHL; 5.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00024};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00024}.
FT DOMAIN 193..233
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 494..537
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 541..584
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 588..631
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 652..682
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 691..730
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 45..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 792 AA; 85794 MW; F4297DF50E528002 CRC64;
MQITPQSGNS KQNSNKDGNV DFNSNDHIFF SNLFNALPRW DAPGKVSSGP VSVPQSASSS
ATSFSNPASL ERDSLNLTDD VLFSNVLGAI GTSSGSAPTN DILGAIGTHM TPSTSPQTNS
SNGSSHCASS LGAVCGRCDT HAISRCLDCN DVLCEDCTHG HSKNTFAKDH CVISIHTISP
IGSAAGAQSI PLANQPHCDV HGEVLRYLCE SCKKIVCQEC TLWDHKDHSC IPVANVSQGA
SEKILSIIES GKLGTKYIKA SIDRAVTYSQ AVERDAMEAS ARIRKAMRHF ILAAEDRERT
LLERVDKFRQ QKLTSLSDQM AGLRAALSGL SQTSDMLTKA LDSVATMNNM DIAKTLTAGE
NQMEQFAAMY KNLQPKEEFI TFVAPNFELL QDIRMQGDVL LVGQRSNSFS NGSNVCIQPP
SGNILTRRPI VRSSTPAQRL SSSSSWDQIP SSKTVLGTSP TSIGIGPIPG MPVLGQCIPG
CTSHVSAKPA VGPSTTFGFD GHEDGQVSRP WGIAVDKDGH VLVADRRNNR VQVFYPDGTF
KLKFGSKGTA NGQFDLPAGI CTDGQNRIIV VDKDNHRVQV FSANGLFLLK FGSYGKDCGQ
FQYPWDVAVN IKGEILVTDS RNHRIQLFNS EGQFISRFSF DGVNHSRYLK GLTTPRGACF
TPQGDVIISD FENHRLLLID ATLTKVLAAK GHEGTAVHEF SRPSGICCDD DGRVIVADSK
NQRVLIFSPQ LEFLWAVEIR PSSNNLLTMG MDEKDRPSDV ALLPDGRLVV MVETSPDARD
QCSPQKTFIQ IY
//
