ID Q16W01_AEDAE Unreviewed; 173 AA.
AC Q16W01;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=N-alpha-acetyltransferase 20 {ECO:0000256|ARBA:ARBA00039529};
DE EC=2.3.1.254 {ECO:0000256|ARBA:ARBA00039120};
DE AltName: Full=Methionine N-acetyltransferase {ECO:0000256|ARBA:ARBA00042723};
DE AltName: Full=N-acetyltransferase 5 {ECO:0000256|ARBA:ARBA00041220};
DE AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAA20 {ECO:0000256|ARBA:ARBA00042743};
DE AltName: Full=N-terminal acetyltransferase B complex catalytic subunit NAT5 {ECO:0000256|ARBA:ARBA00042702};
DE AltName: Full=NatB catalytic subunit {ECO:0000256|ARBA:ARBA00042295};
GN Name=5571897 {ECO:0000313|EnsemblMetazoa:AAEL009373-PA};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL009373-PA, ECO:0000313|Proteomes:UP000008820};
RN [1] {ECO:0000313|EnsemblMetazoa:AAEL009373-PA, ECO:0000313|Proteomes:UP000008820}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL009373-PA,
RC ECO:0000313|Proteomes:UP000008820};
RG Aedes aegypti Genome Working Group (AGWG);
RA Matthews B.J.;
RT "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblMetazoa:AAEL009373-PA}
RP IDENTIFICATION.
RC STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL009373-PA};
RG EnsemblMetazoa;
RL Submitted (MAY-2020) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-asparaginyl-[protein] =
CC CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-
CC [protein]; Xref=Rhea:RHEA:50484, Rhea:RHEA-COMP:12694, Rhea:RHEA-
CC COMP:12695, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133356, ChEBI:CHEBI:133358; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00036044};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-aspartyl-[protein] = CoA
CC + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein];
CC Xref=Rhea:RHEA:50480, Rhea:RHEA-COMP:12692, Rhea:RHEA-COMP:12693,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133045, ChEBI:CHEBI:133063; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00035918};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutaminyl-[protein] =
CC CoA + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-
CC [protein]; Xref=Rhea:RHEA:50492, Rhea:RHEA-COMP:12698, Rhea:RHEA-
CC COMP:12699, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133361, ChEBI:CHEBI:133362; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00036121};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + N-terminal L-methionyl-L-glutamyl-[protein] = CoA
CC + H(+) + N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein];
CC Xref=Rhea:RHEA:50488, Rhea:RHEA-COMP:12696, Rhea:RHEA-COMP:12697,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:133359, ChEBI:CHEBI:133360; EC=2.3.1.254;
CC Evidence={ECO:0000256|ARBA:ARBA00036101};
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex
CC which is composed of NAA20 and NAA25. {ECO:0000256|ARBA:ARBA00038748}.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. ARD1 subfamily.
CC {ECO:0000256|ARBA:ARBA00025786}.
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DR RefSeq; XP_001653814.1; XM_001653764.1.
DR AlphaFoldDB; Q16W01; -.
DR STRING; 7159.Q16W01; -.
DR PaxDb; 7159-AAEL009373-PA; -.
DR EnsemblMetazoa; AAEL009373-RA; AAEL009373-PA; AAEL009373.
DR GeneID; 5571897; -.
DR KEGG; aag:5571897; -.
DR VEuPathDB; VectorBase:AAEL009373; -.
DR eggNOG; KOG3234; Eukaryota.
DR HOGENOM; CLU_013985_7_1_1; -.
DR InParanoid; Q16W01; -.
DR OMA; GHGENWH; -.
DR OrthoDB; 5471170at2759; -.
DR Proteomes; UP000008820; Chromosome 3.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd04301; NAT_SF; 1.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR000182; GNAT_dom.
DR PANTHER; PTHR45910; N-ALPHA-ACETYLTRANSFERASE 20; 1.
DR PANTHER; PTHR45910:SF1; N-ALPHA-ACETYLTRANSFERASE 20; 1.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000008820}.
FT DOMAIN 2..152
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS51186"
SQ SEQUENCE 173 AA; 20045 MW; 20D5DFCEE4665389 CRC64;
MTTLRPFTCN DMFKFNKVNL DPLTETYCLA FYMQYLAHWP EYFQVAESPS GEIMGYIMGK
AAGHGENWHG HVTALTVSPD YRRLGLAATL MNFLEDVSEK KRCYFVDLFV RVSNKVAIDM
YTKLGYIVYR TVLEYYVGDP DEDAYDMRKA CSRDVHRKSV IPLTHPVRPD EVD
//
