ID Q17EC7_AEDAE Unreviewed; 986 AA.
AC Q17EC7;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 103.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN ORFNames=AAEL003829 {ECO:0000313|EMBL:EAT44850.1};
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159 {ECO:0000313|EMBL:EAT44850.1, ECO:0000313|Proteomes:UP000682892};
RN [1] {ECO:0000313|EMBL:EAT44850.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT44850.1};
RA Loftus B.J., Nene V.M., Hannick L.I., Bidwell S., Haas B., Amedeo P.,
RA Orvis J., Wortman J.R., White O.R., Salzberg S., Shumway M., Koo H.,
RA Zhao Y., Holmes M., Miller J., Schatz M., Pop M., Pai G., Utterback T.,
RA Rogers Y.-H., Kravitz S., Fraser C.M.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EAT44850.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT44850.1};
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
RN [3] {ECO:0000313|EMBL:EAT44850.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Liverpool {ECO:0000313|EMBL:EAT44850.1};
RG VectorBase;
RL Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR EMBL; CH477283; EAT44850.1; -; Genomic_DNA.
DR RefSeq; XP_001657306.1; XM_001657256.1.
DR AlphaFoldDB; Q17EC7; -.
DR STRING; 7159.Q17EC7; -.
DR PaxDb; 7159-AAEL003829-PA; -.
DR GeneID; 5579109; -.
DR KEGG; aag:5579109; -.
DR VEuPathDB; VectorBase:AAEL003829; -.
DR eggNOG; KOG0447; Eukaryota.
DR HOGENOM; CLU_012302_0_0_1; -.
DR OMA; ESQTDAF; -.
DR OrthoDB; 48011at2759; -.
DR PhylomeDB; Q17EC7; -.
DR Proteomes; UP000682892; Unassembled WGS sequence.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 311..586
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 225..277
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 986 AA; 114020 MW; 8BEA8B08170F8DC6 CRC64;
MAQLLRGKAS IDPRFKHIRP TVYALSRVNF SGFTYNGNGS GGSSGGSQRR QNFYYQEFLR
GPKFGGYQYY QSSRGYGMLV GRVLRGVLKL RYLVLGGAIG GGVTLNKRYE EWKDGLPDMK
WLEEVLPDND KWGQFTKSLL AVKDSVKDSI EIDPRLKQLS ENKINEWREW FDKRLDNAIE
AAETQQNPQI ESSFQNLSEL ISDLYGATKE ELRSKNTVNA KSLSAEESRR RVDTLQSQVD
ALQTEIMNVQ LKYQREIEKL EKENRDLRQQ YLILKTNRKQ PQKKRIKKSL IDMYSEVLDE
LSGYDTSYST ADHLPRVVVV GDQSSGKTSV LEAIAQARIF PRGSGEMMTR APVKVTLSEG
PYHVAQFRDS DREYDLTRES DLADLRRDVE IRMRNSVRGG KTVSMDVISM TVKGPGLQRM
VLVDLPGIIS TQTVDMAADT KDSIKHMTEH YMSNPNAIIL CIQDGSVDAE RSNVTDLVSQ
CDPLGKRTIF VLTKVDMAED LADPNRIRKI LSGKLFPMKA LGYFAVVTGR GRKDDSIETI
REYEEKFFKN SKLFQSGVTM SHQVTTRNLS LAVADRFWKM VRETIEQQAD AFKATRFNLE
TEWKNNFPRL RESGRDELFE KAKGEVLDEV VNLSQVSAKK WEELLNDKLW EKLSNYVFEN
VYLPAAQSGS TNSFNTMVDI KLRQWAEQAL PAKSVEAGWE ALQKEFQHLM EVARKTPDHD
DLYDNLKSAV IDEAIRRHSW EDKAIDMLRV IQLNTLEDRS VHDKNEWDQA VRFFESSVKE
KLQHTEQTIS EMFGPTTTQK WLHWRSSTED QNKRKHVKSE LDKILGSDSK HSPTLSYDEL
TTVRKNLQRN NVEVETDYIR ETWYPIYRRH FLKQALNRAY DCRKAYYLYT QQGSDCEINC
SDVVLFWRIQ QVIKVTANAL RQQVINREAR RLDKEIKEVL DEYGEDDEKK QQLLTGKRVT
LAEELIRVRH IQEKLEEFIN ALNQEK
//
