UniProt: Q17KA3

Database: UniProt
Entry: Q17KA3_AEDAE

LinkDB:  Q17KA3_AEDAE 
Original site:  Q17KA3_AEDAE

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (10)   
   InterPro (6)   
   Pfam (1)   
   PROSITE (3)   
All databases (17)   

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ID   Q17KA3_AEDAE            Unreviewed;       506 AA.
AC   Q17KA3;
DT   25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT   25-JUL-2006, sequence version 1.
DT   27-MAR-2024, entry version 108.
DE   RecName: Full=Deoxyribodipyrimidine photo-lyase {ECO:0000256|ARBA:ARBA00014046};
DE            EC=4.1.99.3 {ECO:0000256|ARBA:ARBA00013149};
DE   AltName: Full=DNA photolyase {ECO:0000256|ARBA:ARBA00031671};
GN   Name=5572270 {ECO:0000313|EnsemblMetazoa:AAEL001787-PE};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000313|EnsemblMetazoa:AAEL001787-PE, ECO:0000313|Proteomes:UP000008820};
RN   [1] {ECO:0000313|EnsemblMetazoa:AAEL001787-PE, ECO:0000313|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL001787-PE,
RC   ECO:0000313|Proteomes:UP000008820};
RG   Aedes aegypti Genome Working Group (AGWG);
RA   Matthews B.J.;
RT   "Aedes aegypti genome working group (AGWG) sequencing and assembly.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblMetazoa:AAEL001787-PE}
RP   IDENTIFICATION.
RC   STRAIN=LVP_AGWG {ECO:0000313|EnsemblMetazoa:AAEL001787-PE};
RG   EnsemblMetazoa;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in
CC         DNA).; EC=4.1.99.3; Evidence={ECO:0000256|ARBA:ARBA00033999};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the DNA photolyase class-2 family.
CC       {ECO:0000256|ARBA:ARBA00006409}.
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DR   RefSeq; XP_001653955.1; XM_001653905.1.
DR   STRING; 7159.Q17KA3; -.
DR   PaxDb; 7159-AAEL001787-PA; -.
DR   EnsemblMetazoa; AAEL001787-RA; AAEL001787-PA; AAEL001787.
DR   EnsemblMetazoa; AAEL001787-RE; AAEL001787-PE; AAEL001787.
DR   GeneID; 5572270; -.
DR   KEGG; aag:5572270; -.
DR   VEuPathDB; VectorBase:AAEL001787; -.
DR   eggNOG; KOG0133; Eukaryota.
DR   HOGENOM; CLU_026342_2_1_1; -.
DR   OMA; IHNYLRM; -.
DR   Proteomes; UP000008820; Chromosome 2.
DR   GO; GO:0003904; F:deoxyribodipyrimidine photo-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.80; -; 1.
DR   Gene3D; 1.10.579.10; DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR036134; Crypto/Photolyase_FAD-like_sf.
DR   InterPro; IPR036155; Crypto/Photolyase_N_sf.
DR   InterPro; IPR008148; DNA_photolyase_2.
DR   InterPro; IPR032673; DNA_photolyase_2_CS.
DR   InterPro; IPR006050; DNA_photolyase_N.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   NCBIfam; TIGR00591; phr2; 1.
DR   PANTHER; PTHR10211:SF0; DEOXYRIBODIPYRIMIDINE PHOTO-LYASE; 1.
DR   PANTHER; PTHR10211; DEOXYRIBODIPYRIMIDINE PHOTOLYASE; 1.
DR   Pfam; PF00875; DNA_photolyase; 1.
DR   SUPFAM; SSF48173; Cryptochrome/photolyase FAD-binding domain; 1.
DR   SUPFAM; SSF52425; Cryptochrome/photolyase, N-terminal domain; 1.
DR   PROSITE; PS01083; DNA_PHOTOLYASES_2_1; 1.
DR   PROSITE; PS01084; DNA_PHOTOLYASES_2_2; 1.
DR   PROSITE; PS51645; PHR_CRY_ALPHA_BETA; 1.
PE   3: Inferred from homology;
KW   Chromophore {ECO:0000256|ARBA:ARBA00022991};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   FAD {ECO:0000256|ARBA:ARBA00022827};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008820};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          68..200
FT                   /note="Photolyase/cryptochrome alpha/beta"
FT                   /evidence="ECO:0000259|PROSITE:PS51645"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   506 AA;  58653 MW;  7D9BE822024A2944 CRC64;
     MKKASSSKAD GPAEKKPKVE GGPIKVDDFV EKFKTIRKET AKSILDFDFK KKRVRILSDA
     KEVEENKKGV IYWMSRDARV QDNWAFLFAQ KLALKNELPL HVCFSLVPKF LDATIRHYKF
     MLKGLEEVAK ECESLNINFH MLTGMAKDTI PKFVKTHNIG AVVCDFSPLR VPMKWVEDVR
     KSLPAEVPLC QVDAHNIVPL WVTSEKQEYA ARTIRNKVNN NLNTYLTQFP PVIKHPHKAS
     FKADSIDWVK LLDTIEVDRT VDEVDWAVPG YTGGIGVLQS FVEKRLRKFN AKRNDPTDDA
     LSNLSPWFHF GQISVQRCVL AVKKYGKGYS EGVAAFCEES IVRRELSDNF CYYNKNYDNL
     KGAYDWAQKT LDDHRKDKRT YVYSRDQLEQ ARTHDDLWNS AQIQMVKEGK MHGFLRMYWA
     KKILEWTKTP EEALETAIYL NDRYQLDGRD PNGYVGCMWS IAGIHDQGWR EREVFGKIRY
     MNYEGCKRKF DVAAFVARYG GKVYKK
//

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