ID EMX2_BOVIN Reviewed; 253 AA.
AC Q17R00;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 118.
DE RecName: Full=Homeobox protein EMX2;
DE AltName: Full=Empty spiracles homolog 2;
DE AltName: Full=Empty spiracles-like protein 2;
GN Name=EMX2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor, which in cooperation with EMX1, acts to
CC generate the boundary between the roof and archipallium in the
CC developing brain. May function in combination with OTX1/2 to specify
CC cell fates in the developing central nervous system (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with translation initiation factor EIF4E.
CC {ECO:0000250|UniProtKB:Q04744}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04744}. Cell
CC projection, axon {ECO:0000250|UniProtKB:Q04744}. Note=Detected in axons
CC within the olfactory mucosa and glomeruli in the olfactory bulb.
CC {ECO:0000250|UniProtKB:Q04744}.
CC -!- SIMILARITY: Belongs to the EMX homeobox family. {ECO:0000305}.
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DR EMBL; BC118094; AAI18095.1; -; mRNA.
DR RefSeq; NP_001069313.1; NM_001075845.1.
DR AlphaFoldDB; Q17R00; -.
DR SMR; Q17R00; -.
DR STRING; 9913.ENSBTAP00000003937; -.
DR PaxDb; 9913-ENSBTAP00000003937; -.
DR Ensembl; ENSBTAT00000003937.5; ENSBTAP00000003937.4; ENSBTAG00000003027.5.
DR GeneID; 523601; -.
DR KEGG; bta:523601; -.
DR CTD; 2018; -.
DR VEuPathDB; HostDB:ENSBTAG00000003027; -.
DR VGNC; VGNC:28486; EMX2.
DR eggNOG; KOG0843; Eukaryota.
DR GeneTree; ENSGT00940000157425; -.
DR HOGENOM; CLU_049668_1_0_1; -.
DR InParanoid; Q17R00; -.
DR OMA; RWRMETQ; -.
DR OrthoDB; 903523at2759; -.
DR TreeFam; TF317015; -.
DR Proteomes; UP000009136; Chromosome 26.
DR Bgee; ENSBTAG00000003027; Expressed in mammary gland fat and 78 other cell types or tissues.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0021846; P:cell proliferation in forebrain; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0021796; P:cerebral cortex regionalization; IEA:Ensembl.
DR GO; GO:0021542; P:dentate gyrus development; IEA:Ensembl.
DR GO; GO:0021885; P:forebrain cell migration; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0072197; P:ureter morphogenesis; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24339; HOMEOBOX PROTEIN EMX-RELATED; 1.
DR PANTHER; PTHR24339:SF25; HOMEOBOX PROTEIN EMX2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome.
FT CHAIN 1..253
FT /note="Homeobox protein EMX2"
FT /id="PRO_0000285082"
FT DNA_BIND 155..214
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 213..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 253 AA; 28344 MW; AAE6D2F46786B21E CRC64;
MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAA
GRGVYSNPDL VFAEAVSHPP NPAVPVHPVP PPHALAAHPL PSSHSPHPLF ASQQRDPSTF
YPWLIHRYRY LGHRFQGNDA SPESFLLHNA LARKPKRIRT AFSPSQLLRL EHAFEKNHYV
VGAERKQLAH SLSLTETQVK VWFQNRRTKF KRQKLEEEGS DSQQKKKGTH HINRWRIATK
QASPEEIDVT SDD
//
