ID Q17Y63_HELAH Unreviewed; 258 AA.
AC Q17Y63;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=beta-lactamase {ECO:0000256|ARBA:ARBA00012865};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865};
GN OrderedLocusNames=Hac_0600 {ECO:0000313|EMBL:CAJ99413.1};
OS Helicobacter acinonychis (strain Sheeba).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=382638 {ECO:0000313|EMBL:CAJ99413.1, ECO:0000313|Proteomes:UP000000775};
RN [1] {ECO:0000313|EMBL:CAJ99413.1, ECO:0000313|Proteomes:UP000000775}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sheeba {ECO:0000313|EMBL:CAJ99413.1,
RC ECO:0000313|Proteomes:UP000000775};
RX PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA Gressmann H., Achtman M., Schuster S.C.;
RT "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT host jump from early humans to large felines.";
RL PLoS Genet. 2:1097-1110(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526};
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DR EMBL; AM260522; CAJ99413.1; -; Genomic_DNA.
DR RefSeq; WP_011577527.1; NC_008229.1.
DR AlphaFoldDB; Q17Y63; -.
DR KEGG; hac:Hac_0600; -.
DR eggNOG; COG0790; Bacteria.
DR HOGENOM; CLU_000288_36_7_7; -.
DR OrthoDB; 5372609at2; -.
DR BioCyc; HACI382638:HAC_RS02650-MONOMER; -.
DR Proteomes; UP000000775; Chromosome.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-EC.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR006597; Sel1-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR11102:SF147; FIBRONECTIN TYPE-II DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11102; SEL-1-LIKE PROTEIN; 1.
DR Pfam; PF08238; Sel1; 6.
DR SMART; SM00671; SEL1; 6.
DR SUPFAM; SSF81901; HCP-like; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}.
SQ SEQUENCE 258 AA; 28924 MW; 5B21CB2E3E8ABFFD CRC64;
MGYASKLALK IGLIGLCLFG TLNGVEHLGH KGSFVYRGEV AYNNKDYERA VSLYKDAIKN
GESIAYVLLG IMYKDGRGVP RNDKKAVEYF KKAVALDIPR GYNNLGVMYK EGRGVPKDEK
KAVEYFQMAA NKGYTSAYMN LGIMYMEGRG VPSSYMKATE YFRLAMAKGS AEAYILLGDL
YYSGNEQLGI EQDKEKAVIY YKMAADVGSS QAYEGLAKSY EYGLGVEKDK KQAEEFRQRA
CDYDLDKNCR KRNASSHH
//
