ID Q180U7_CLOD6 Unreviewed; 387 AA.
AC Q180U7;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 2.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Phosphosugar isomerase putative tagatose-6-phosphate ketose/aldose isomerase AgaS {ECO:0000313|EMBL:CAJ70352.2};
DE EC=5.-.-.- {ECO:0000313|EMBL:CAJ70352.2};
GN OrderedLocusNames=CD630_34490 {ECO:0000313|EMBL:CAJ70352.2};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ70352.2, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ70352.2, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ70352.2,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-galactosamine 6-phosphate + H2O = D-tagatopyranose 1-
CC phosphate + NH4(+); Xref=Rhea:RHEA:47680, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:71674, ChEBI:CHEBI:138150;
CC Evidence={ECO:0000256|ARBA:ARBA00029292};
CC -!- SIMILARITY: Belongs to the SIS family. AgaS subfamily.
CC {ECO:0000256|ARBA:ARBA00007748}.
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DR EMBL; AM180355; CAJ70352.2; -; Genomic_DNA.
DR RefSeq; WP_009898687.1; NZ_JAUPES010000009.1.
DR RefSeq; YP_001089969.2; NC_009089.1.
DR AlphaFoldDB; Q180U7; -.
DR STRING; 272563.CD630_34490; -.
DR DNASU; 4913401; -.
DR EnsemblBacteria; CAJ70352; CAJ70352; CD630_34490.
DR GeneID; 66355910; -.
DR KEGG; cdf:CD630_34490; -.
DR KEGG; pdc:CDIF630_03760; -.
DR PATRIC; fig|272563.120.peg.3645; -.
DR eggNOG; COG2222; Bacteria.
DR OrthoDB; 9779207at2; -.
DR PhylomeDB; Q180U7; -.
DR BioCyc; PDIF272563:G12WB-3628-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR CDD; cd05010; SIS_AgaS_like; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR035464; SIS_AgaS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR32502:SF3; D-GALACTOSAMINE-6-PHOSPHATE DEAMINASE AGAS-RELATED; 1.
DR PANTHER; PTHR32502; N-ACETYLGALACTOSAMINE PERMEASE II COMPONENT-RELATED; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Isomerase {ECO:0000313|EMBL:CAJ70352.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 45..201
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
FT DOMAIN 221..369
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 387 AA; 43773 MW; 3EC63F1342E043AC CRC64;
MFKLEEQKLK DLGAIITTNE IKQQPELWLE TYEIYKSNKE KLSRFIDTIS NNHGQFRVIF
TGAGTSAYIG NSILPYLKNK NDIRKYIFEA IPTTDIVSNP YDYLKKDIPT LLISFARSGN
SPESLAALNL GNKIVDNFYH LAITCNPEGE LAKMTKNDEN NYLLLMPSKS NDEGFAMTGS
FSCMMLSAML IFDSLEDDVE KSYINAIIEM GRNVIDRKDE IHELINKDFD RVVYLGSGGL
GGLTQEAQLK LLELTAGKIS TVYDSPMGFR HGPKSFIDEN TLVFEFVSNC LYTRKYDLDV
LEEIKRDKIA KFTCAVSVEN ENNFSGTKFE FKEKYNKLPD VYLAMPYILF AQTIALFVSV
KVGNKPDTPS ATGTVNRVVK GVTIYEY
//
