ID Q18351_CAEEL Unreviewed; 529 AA.
AC Q18351;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2005, sequence version 3.
DT 24-JAN-2024, entry version 171.
DE SubName: Full=BTB domain-containing protein {ECO:0000313|EMBL:CAA98109.3};
GN Name=kvs-2 {ECO:0000313|EMBL:CAA98109.3,
GN ECO:0000313|WormBase:C32C4.1a};
GN ORFNames=C32C4.1 {ECO:0000313|WormBase:C32C4.1a}, CELE_C32C4.1
GN {ECO:0000313|EMBL:CAA98109.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAA98109.3, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAA98109.3, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAA98109.3,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; BX284605; CAA98109.3; -; Genomic_DNA.
DR PIR; T19635; T19635.
DR RefSeq; NP_505725.3; NM_073324.4.
DR AlphaFoldDB; Q18351; -.
DR SMR; Q18351; -.
DR EnsemblMetazoa; C32C4.1a.1; C32C4.1a.1; WBGene00007862.
DR GeneID; 183120; -.
DR UCSC; C32C4.1a; c. elegans.
DR AGR; WB:WBGene00007862; -.
DR WormBase; C32C4.1a; CE37877; WBGene00007862; kvs-2.
DR GeneTree; ENSGT00970000196337; -.
DR OrthoDB; 1478695at2759; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00007862; Expressed in larva and 3 other cell types or tissues.
DR ExpressionAtlas; Q18351; baseline and differential.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IBA:GO_Central.
DR GO; GO:0005251; F:delayed rectifier potassium channel activity; IBA:GO_Central.
DR GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18317; BTB_POZ_Kv; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR11537:SF121; BTB DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01494; KV9CHANNEL.
DR PRINTS; PR01491; KVCHANNEL.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 211..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..169
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
SQ SEQUENCE 529 AA; 60125 MW; D48BA24DB1E33559 CRC64;
MFSSVSKSNL NVAKIAKQQR LQAEENAAVQ AASMERRVAF RPPPIGESRS TTITHDSGSN
ADTYMRLNVG GKSYYVRAEL YTSEWTRMHE LLDSSHEERL KMVDGFDSKT GEYYLERNAK
LTDHVMDFFV TGSLHKPQNV CVERFKEELE YWKIKPDQLS TCCQIPSEHH VRKLSRGTSF
NEDDYVTDFD GACFAGPRLA MWKFLEDPQS SVFAAVFALL SVFFVFASVV GLILGSMPEF
QADSSNAATY HVMHVRSRPN DYGNKFGNDD DVAPNELLKD FVYKPTDSPN LPLTILEYIC
IGWFTFEYLV RFTIYPRKRQ FVKKTLNIID LSTILPFYLE ICLPLFGVES RLKEFTGAML
VVRVLRVLRM ARVFKLARYS TSLQTFGHTL QSSITELSML SMFLITGIVF FSTIMYYLEK
DEPHTDFYSI PAGCWWCVVT MATVGYGDAK PVTTLGKLVA TSTSICGIIV LAFPISMIVE
KFATAQQRAI EDQQIQQAQM SAVANNALLR RFPTRRKVRR NTTVSVNNI
//
