ID Q183N4_CLOD6 Unreviewed; 631 AA.
AC Q183N4;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Cell wall binding protein cwp8 {ECO:0000313|EMBL:CAJ69687.1};
GN Name=cwp8 {ECO:0000313|EMBL:CAJ69687.1};
GN OrderedLocusNames=CD630_27990 {ECO:0000313|EMBL:CAJ69687.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69687.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ69687.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ69687.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
RN [2] {ECO:0007829|PDB:5J6Q}
RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 35-629.
RX PubMed=28132783; DOI=10.1016/j.str.2016.12.018;
RA Usenik A., Renko M., Mihelic M., Lindic N., Borisek J., Perdih A.,
RA Pretnar G., Muller U., Turk D.;
RT "The CWB2 Cell Wall-Anchoring Module Is Revealed by the Crystal Structures
RT of the Clostridium difficile Cell Wall Proteins Cwp8 and Cwp6.";
RL Structure 25:514-521(2017).
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DR EMBL; AM180355; CAJ69687.1; -; Genomic_DNA.
DR RefSeq; WP_011861692.1; NZ_JAUPES010000010.1.
DR RefSeq; YP_001089312.1; NC_009089.1.
DR PDB; 5J6Q; X-ray; 2.10 A; A=35-629.
DR PDBsum; 5J6Q; -.
DR AlphaFoldDB; Q183N4; -.
DR SMR; Q183N4; -.
DR STRING; 272563.CD630_27990; -.
DR EnsemblBacteria; CAJ69687; CAJ69687; CD630_27990.
DR KEGG; cdf:CD630_27990; -.
DR KEGG; pdc:CDIF630_03063; -.
DR PATRIC; fig|272563.120.peg.2947; -.
DR eggNOG; COG2247; Bacteria.
DR OrthoDB; 1744233at2; -.
DR PhylomeDB; Q183N4; -.
DR BioCyc; PDIF272563:G12WB-2958-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR Gene3D; 3.40.50.12090; -; 2.
DR InterPro; IPR007253; Cell_wall-bd_2.
DR PANTHER; PTHR30032; N-ACETYLMURAMOYL-L-ALANINE AMIDASE-RELATED; 1.
DR PANTHER; PTHR30032:SF4; STAGE II SPORULATION PROTEIN D; 1.
DR Pfam; PF04122; CW_binding_2; 3.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5J6Q};
KW Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..631
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004186822"
SQ SEQUENCE 631 AA; 68495 MW; 548B4801A24C0C6B CRC64;
MLSNKKRSMA IVMAGATVMS AAAPIFADNT VTENVDKNYT VSAKDSAKLI EEVRKALEVK
FEDTKAGANV NDRVYDIKVD NVNLTNATQL QNKINSLTEG QSLKVTIQDK GHQVLGGKVV
DYKIENYKTA QEIVDAVNAY NATLAEDSDN KLTATIKSTN TVEVKRAKDS ANVITLNVGD
QHLDFSKVIT SEEGTFEGYE KRYSDIDSKE LHTVTVKNAD LQDISAEELF DGIRLTTLGR
EIVNKVKNGY ALTFENEAIL TQEQEDSDDK DKPEKSSFDI VLSKANEKPE TISVSSKNHK
LVRDLHKVLT DVKDGKELKV EVLSGDSRFT TAVEVSKERF KDGEAEAIIL VGEDAIVDGL
ASAPLASQKN APILLSKKDS LPSEIEAEIL RVLGSNLSSK KIYIVGGESK VSKETEEKLS
KLGVSKVERV SGEDRFETSL EIAKQLKDTF KTAFVVGGNG EADAMSISAR AAQFGAPIIV
TGNELDANAE KLLKGKELEI VGGENSVSKE VEDKLVDIDL NNKVERLAGE NRKDTNAKVI
NKYYAGATKA YVAKDGYVGG NGQLVDALTA APLAASSKAP IVLTTEELSK SQEEVVELRL
KNATKLVQIG EGIAKNAIEK IAEKINLFTK N
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