ID Q183S5_CLOD6 Unreviewed; 501 AA.
AC Q183S5;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Two-component sensor histidine kinase {ECO:0000313|EMBL:CAJ69727.1};
GN OrderedLocusNames=CD630_28390 {ECO:0000313|EMBL:CAJ69727.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69727.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ69727.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ69727.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
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DR EMBL; AM180355; CAJ69727.1; -; Genomic_DNA.
DR RefSeq; WP_011861709.1; NZ_JAUPES010000029.1.
DR RefSeq; YP_001089352.1; NC_009089.1.
DR AlphaFoldDB; Q183S5; -.
DR STRING; 272563.CD630_28390; -.
DR DNASU; 4915406; -.
DR EnsemblBacteria; CAJ69727; CAJ69727; CD630_28390.
DR KEGG; cdf:CD630_28390; -.
DR KEGG; pdc:CDIF630_03106; -.
DR PATRIC; fig|272563.120.peg.2991; -.
DR eggNOG; COG0662; Bacteria.
DR eggNOG; COG2972; Bacteria.
DR OrthoDB; 9809348at2; -.
DR PhylomeDB; Q183S5; -.
DR BioCyc; PDIF272563:G12WB-2999-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd02208; cupin_RmlC-like; 1.
DR CDD; cd16956; HATPase_YehU-like; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR013096; Cupin_2.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR InterPro; IPR010559; Sig_transdc_His_kin_internal.
DR PANTHER; PTHR34220; SENSOR HISTIDINE KINASE YPDA; 1.
DR PANTHER; PTHR34220:SF7; SENSOR HISTIDINE KINASE YPDA; 1.
DR Pfam; PF07883; Cupin_2; 1.
DR Pfam; PF06580; His_kinase; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:CAJ69727.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW Transferase {ECO:0000313|EMBL:CAJ69727.1}.
FT DOMAIN 34..96
FT /note="Cupin type-2"
FT /evidence="ECO:0000259|Pfam:PF07883"
FT DOMAIN 303..376
FT /note="Signal transduction histidine kinase internal
FT region"
FT /evidence="ECO:0000259|Pfam:PF06580"
SQ SEQUENCE 501 AA; 58266 MW; BE86FBD521A6FFE6 CRC64;
MKIQNTEWGY IEWKHTYDEN NPKQAMNIYI AVTMPGKKHF NHVHYGQEQM IYILEGEGLY
IINGVWKPFY QGMIFYIESG STHETINTGD REIKELIVSN NVDDVGESEI IDINPNNYLK
KTLINYSEST LNLYAAVESI RGQFIDPFKI PLIIYDDSWN IVLKNPYFPL FCFEKCNPMK
FPQNCDCMNQ KSSNQFVCEY GITIYNIPIL YKSNSIGVIR GGYVLLSDLN LDTEHNNLYD
IPEGAARSIK RLLKQISKNI INFCSFNDIR KDLQEKEKTI ARTYHYGEQL EMNLKVAQDM
VTNLRINHHF LFNTLNSMAS IALDDGSYDL YSAIIDLSRM FRYTMRSDLR FVELESEILY
IKNYLNLQKL RYGDALKVKY LIPEKLYNLS VPFNFIQPIV ENAFTHGFRD IDTEKRIEII
ARLDSQYAII EIHNNGTILD GNNIDKIKAG IRSNNGHGLS LIYTKFTSAY GNNFDMDIKS
SDNEGTYIMI KIPIENYKEY V
//
