ID Q184J6_CLOD6 Unreviewed; 258 AA.
AC Q184J6;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Transcriptional regulator, IclR family {ECO:0000313|EMBL:CAJ69899.1};
GN OrderedLocusNames=CD630_30050 {ECO:0000313|EMBL:CAJ69899.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69899.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ69899.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ69899.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
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DR EMBL; AM180355; CAJ69899.1; -; Genomic_DNA.
DR RefSeq; WP_003439844.1; NZ_JAUPES010000017.1.
DR RefSeq; YP_001089523.1; NC_009089.1.
DR AlphaFoldDB; Q184J6; -.
DR STRING; 272563.CD630_30050; -.
DR EnsemblBacteria; CAJ69899; CAJ69899; CD630_30050.
DR GeneID; 66355404; -.
DR KEGG; cdf:CD630_30050; -.
DR KEGG; pdc:CDIF630_03290; -.
DR PATRIC; fig|272563.120.peg.3172; -.
DR eggNOG; COG1414; Bacteria.
DR OrthoDB; 9791752at2; -.
DR PhylomeDB; Q184J6; -.
DR BioCyc; PDIF272563:G12WB-3170-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF24; HTH-TYPE TRANSCRIPTIONAL REPRESSOR ALLR; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 6..68
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 69..250
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
SQ SEQUENCE 258 AA; 29048 MW; 742CCEC37BA72DE9 CRC64;
MTSDNHRPTA RILDILEALA ESENGYTLTE IADVINAPKS SIFPIVHTLN ARKYITIDKN
TSKYSIGIRS YTLGSSFFEK RTIFNYIIDE MTNIVNSCSE TCQLGILDNN EVLYIGKVDS
PEPIRLISYV GKKIPANCTG LGKALLCDFD KEKLISLYPD GLKGFTEKSI TDFDVLYDQL
LEVQRTQIAS ECEESMEHLK CLAVPIRKNG CIRAAVSVTL PLFRANDEKI ELIKKLLLNA
QKNIQSMMEE RNEDIVIN
//
