ID Q184R3_CLOD6 Unreviewed; 250 AA.
AC Q184R3;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Transcriptional regulator, RpiR family {ECO:0000313|EMBL:CAJ69969.1};
GN OrderedLocusNames=CD630_30770 {ECO:0000313|EMBL:CAJ69969.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ69969.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ69969.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ69969.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
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DR EMBL; AM180355; CAJ69969.1; -; Genomic_DNA.
DR RefSeq; WP_003427244.1; NZ_JAUPES010000008.1.
DR RefSeq; YP_001089591.1; NC_009089.1.
DR AlphaFoldDB; Q184R3; -.
DR STRING; 272563.CD630_30770; -.
DR DNASU; 4913692; -.
DR EnsemblBacteria; CAJ69969; CAJ69969; CD630_30770.
DR GeneID; 66355480; -.
DR KEGG; cdf:CD630_30770; -.
DR KEGG; pdc:CDIF630_03360; -.
DR PATRIC; fig|272563.120.peg.3243; -.
DR eggNOG; COG1737; Bacteria.
DR OrthoDB; 1648815at2; -.
DR PhylomeDB; Q184R3; -.
DR BioCyc; PDIF272563:G12WB-3238-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR CDD; cd05013; SIS_RpiR; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR000281; HTH_RpiR.
DR InterPro; IPR047640; RpiR-like.
DR InterPro; IPR035472; RpiR-like_SIS.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR30514; GLUCOKINASE; 1.
DR PANTHER; PTHR30514:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATOR HEXR-RELATED; 1.
DR Pfam; PF01418; HTH_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51071; HTH_RPIR; 1.
DR PROSITE; PS51464; SIS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001978}.
FT DOMAIN 1..76
FT /note="HTH rpiR-type"
FT /evidence="ECO:0000259|PROSITE:PS51071"
FT DOMAIN 107..244
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 250 AA; 28523 MW; 7D8DA6AC7D42ED40 CRC64;
MIIELNKSNS ENLTKTELEI IKFINENESI LPELSIVEIA HETYSSPATV SRAIRKCGLN
GFNELRYRLT VKDENDDIQN MGDIINKSFI EAQRVIEQIS LTTLINIIKT INKSSKIYIL
ARGLTEYVAK EFSLKLQLLD FNVVFINDPN IMKIKSKSIK KDELIIIFSL NGNTIELVES
AQNANLVGAK VITCCCSESA KLIKYSDLYI VGYKHEHISI SEYEVSSRLP LYIISRIIID
YMVRYNNSEN
//
