ID Q186K7_CLOD6 Unreviewed; 265 AA.
AC Q186K7;
DT 25-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 25-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Lipoprotein {ECO:0000256|PIRNR:PIRNR002854};
GN OrderedLocusNames=CD630_16530 {ECO:0000313|EMBL:CAJ68518.1};
OS Clostridioides difficile (strain 630) (Peptoclostridium difficile).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptostreptococcaceae;
OC Clostridioides.
OX NCBI_TaxID=272563 {ECO:0000313|EMBL:CAJ68518.1, ECO:0000313|Proteomes:UP000001978};
RN [1] {ECO:0000313|EMBL:CAJ68518.1, ECO:0000313|Proteomes:UP000001978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=630 {ECO:0000313|EMBL:CAJ68518.1,
RC ECO:0000313|Proteomes:UP000001978};
RX PubMed=16804543; DOI=10.1038/ng1830;
RA Sebaihia M., Wren B.W., Mullany P., Fairweather N.F., Minton N.,
RA Stabler R., Thomson N.R., Roberts A.P., Cerdeno-Tarraga A.M., Wang H.,
RA Holden M.T.G., Wright A., Churcher C., Quail M.A., Baker S., Bason N.,
RA Brooks K., Chillingworth T., Cronin A., Davis P., Dowd L., Fraser A.,
RA Feltwell T., Hance Z., Holroyd S., Jagels K., Moule S., Mungall K.,
RA Price C., Rabbinowitsch R., Sharp S., Simmonds M., Steven K., Unwin L.,
RA Whithead S., Dupuy B., Dougan G., Barrell B.and.Parkhill.J.;
RT "The multidrug-resistant human pathogen Clostridium difficile has a highly
RT mobile, mosaic genome.";
RL Nat. Genet. 38:779-786(2006).
RN [2] {ECO:0007829|PDB:4OTE}
RP X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 25-265 IN COMPLEX WITH ZINC.
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of a putative lipoprotein (CD630_1653) from Clostridium
RT difficile 630 at 2.20 A resolution.";
RL Submitted (FEB-2014) to the PDB data bank.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the nlpA lipoprotein family.
CC {ECO:0000256|PIRNR:PIRNR002854}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM180355; CAJ68518.1; -; Genomic_DNA.
DR RefSeq; WP_003420312.1; NZ_JAUPES010000013.1.
DR RefSeq; YP_001088154.1; NC_009089.1.
DR PDB; 4OTE; X-ray; 2.20 A; A/B=26-265.
DR PDBsum; 4OTE; -.
DR AlphaFoldDB; Q186K7; -.
DR SMR; Q186K7; -.
DR STRING; 272563.CD630_16530; -.
DR DNASU; 4915341; -.
DR EnsemblBacteria; CAJ68518; CAJ68518; CD630_16530.
DR GeneID; 66354065; -.
DR KEGG; cdf:CD630_16530; -.
DR KEGG; pdc:CDIF630_01830; -.
DR PATRIC; fig|272563.120.peg.1731; -.
DR eggNOG; COG1464; Bacteria.
DR OrthoDB; 9812878at2; -.
DR PhylomeDB; Q186K7; -.
DR BioCyc; PDIF272563:G12WB-1792-MONOMER; -.
DR Proteomes; UP000001978; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR004872; Lipoprotein_NlpA.
DR PANTHER; PTHR30429; D-METHIONINE-BINDING LIPOPROTEIN METQ; 1.
DR PANTHER; PTHR30429:SF0; METHIONINE-BINDING LIPOPROTEIN METQ; 1.
DR Pfam; PF03180; Lipoprotein_9; 1.
DR PIRSF; PIRSF002854; MetQ; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4OTE};
KW Lipoprotein {ECO:0000256|PIRNR:PIRNR002854, ECO:0000313|EMBL:CAJ68518.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0007829|PDB:4OTE};
KW Reference proteome {ECO:0000313|Proteomes:UP000001978};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0007829|PDB:4OTE}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..265
FT /note="Lipoprotein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004186799"
FT BINDING 42
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 64
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 65
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 79
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 230
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 231
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="4"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 231
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="3"
FT /evidence="ECO:0007829|PDB:4OTE"
FT BINDING 247
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="5"
FT /evidence="ECO:0007829|PDB:4OTE"
FT LIPID 22
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000256|PIRSR:PIRSR002854-1"
SQ SEQUENCE 265 AA; 29222 MW; 362F6169D21BDECA CRC64;
MKFKKLLCLL LCLVLTLAVV GCSKAKDDKK IVVGATLVPG GELLEELKPL IKEKGYTLEV
KNFDDYILPN EALNNGEIDA NLFQHEPYLK EAVKAKGYKI MAGKKLYVCP AILYSYKIKS
VDEFKKGDTI AISNNPSSCS KNLRYLESIG LLTLPKGDGL VSPKDIIENP KGIQFKELDI
AQIPSSLPDV TAAFIDTTYA VPAGLDAKKN GIYTAPINDE YANLLAFRTE DKDSEKIKVL
QDVLTSDKAR SLIEEKYKGI VIPTF
//
