ID Q19AB2_MOUSE Unreviewed; 1508 AA.
AC Q19AB2;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 146.
DE SubName: Full=ROBO2 isoform b {ECO:0000313|EMBL:ABF83433.1};
DE SubName: Full=Roundabout guidance receptor 2 {ECO:0000313|Ensembl:ENSMUSP00000112776.2};
GN Name=Robo2 {ECO:0000313|Ensembl:ENSMUSP00000112776.2,
GN ECO:0000313|MGI:MGI:1890110};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:ABF83433.1};
RN [1] {ECO:0000313|EMBL:ABF83433.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16829019; DOI=10.1016/j.ygeno.2006.05.011;
RA Yue Y., Grossmann B., Galetzka D., Zechner U., Haaf T.;
RT "Isolation and differential expression of two isoforms of the ROBO2/Robo2
RT axon guidance receptor gene in humans and mice.";
RL Genomics 88:772-778(2006).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000112776.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112776.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4] {ECO:0000313|Ensembl:ENSMUSP00000112776.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000112776.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; DQ533876; ABF83433.1; -; mRNA.
DR RefSeq; NP_780758.3; NM_175549.4.
DR ProteomicsDB; 332984; -.
DR Antibodypedia; 2693; 284 antibodies from 34 providers.
DR DNASU; 268902; -.
DR Ensembl; ENSMUST00000117785.9; ENSMUSP00000112776.2; ENSMUSG00000052516.20.
DR GeneID; 268902; -.
DR UCSC; uc007zrh.1; mouse.
DR AGR; MGI:1890110; -.
DR CTD; 6092; -.
DR MGI; MGI:1890110; Robo2.
DR VEuPathDB; HostDB:ENSMUSG00000052516; -.
DR GeneTree; ENSGT00940000156324; -.
DR OrthoDB; 5396194at2759; -.
DR TreeFam; TF351053; -.
DR BioGRID-ORCS; 268902; 1 hit in 61 CRISPR screens.
DR ChiTaRS; Robo2; mouse.
DR Proteomes; UP000000589; Chromosome 16.
DR Bgee; ENSMUSG00000052516; Expressed in rostral migratory stream and 200 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF52; ROUNDABOUT HOMOLOG 2; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 1: Evidence at protein level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|MaxQB:Q19AB2,
KW ECO:0007829|PeptideAtlas:Q19AB2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1508
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015097045"
FT TRANSMEM 860..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..127
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 133..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..309
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 314..409
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 417..504
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 524..618
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 637..735
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 739..836
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1062..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1167..1197
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1421..1508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1086
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1197
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1254..1268
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1333..1353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1367..1401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1424..1440
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1456..1474
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1508 AA; 165375 MW; 867BB626F0F56B3F CRC64;
MNPLMFTLLL LFGFLCIQID GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP
TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV
SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER
ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE
AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKAMSTDEGT YVCIAENRVG
KVEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE GSQNLLFPNQ
PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII
LQGPINQTLA VDGTALLKCK ATGEPLPVIS WLKEGFTFLG RDPRATIQDQ GTLQIKNLRI
SDTGTYTCVA TSSSGETSWS AVLDVTESGA TISKNYDMND LPGPPSKPQV TDVSKNSVTL
SWQPGTPGVL PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP
QGLSDPSPMS DPVRTQDISP PAQGVDHRQV QKELGDVVVR LHNPVVLTPT TVQVTWTVDR
QPQFIQGYRV MYRQTSGLQA STVWQNLDAK VPTERSAVLV NLKKGVTYEI KVRPYFNEFQ
GMDSESKTVR TTEEAPSAPP QSVTVLTVGS HNSTSISVSW DPPPADHQNG IIQEYKIWCL
GNETRFHINK TVDAAIRSVV IGGLFPGIQY RVEVAASTSA GVGVKSEPQP IIIGGRNEVV
ITENNNSITE QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL SNYAVTFQRG
DGGLMSNGSR PGLLNAGDPN YPWLADSWPA TSLPVNNSNS GPNEIGNFGR GDVLPPVPGQ
GDKTATMLSD GAIYSSIDFT TKTTYNSSSQ ITQATPYATT QILHSNSIHE LAVDLPDPQW
KSSVQQKTDL MGFGYSLPDQ NKGNNALLYI PDYRLAEGLS NRMPHNQSQD FSTTSSHNSS
ERSGSLSGGK GGKKKKTKNS SKAQKNNGST WANVPLPPPP VQPLPGTELG HYAAEQENGY
DSDSWCPPLP VQTYLHQGME DELEEDEDRV PTPPVRGVAS SPAISFGQQS TATLTPSPRE
EMQPMLQAHL DELTRAYQFD IAKQTWHIQS NTPPPQPPAP PLGYVSGALI SDLETDVPDE
DADDEEEPLE IPRPLRALDQ TPGSSMDNLD SSVTGKAFSS SQRQRPTSPF STDSNTSAAQ
NQSQRPRPTK KHKGGRMDPQ PVLPHRREGM PDDLPPPPDP PPGQGLRQQI GLSQHSGNVE
NSTERKGSSL ERQQAANLED TKSSLDCPAK TVLEWQRQTQ DWINSTERQE ETRKAPHKQG
VGSEESLVPY SKPSFPSPGG HSSSGTSSSK GSTGPRKADV LRGSHQRNAN DLLDIGYVGS
NSQGQFTE
//
