ID Q1AHA7_ENTCL Unreviewed; 291 AA.
AC Q1AHA7;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN Name=blaCTX-M-9 {ECO:0000313|EMBL:AAZ30046.1};
OS Enterobacter cloacae.
OG Plasmid pQC {ECO:0000313|EMBL:AAZ30046.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=550 {ECO:0000313|EMBL:AAZ30046.1};
RN [1] {ECO:0000313|EMBL:AAZ30046.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pQC {ECO:0000313|EMBL:AAZ30046.1};
RX PubMed=16704842;
RA Paauw A., Fluit A.C., Verhoef J., Leverstein-van Hall M.A.;
RT "Enterobacter cloacae outbreak and emergence of quinolone resistance gene
RT in Dutch hospital.";
RL Emerg. Infect. Dis. 12:807-812(2006).
RN [2] {ECO:0000313|EMBL:ADK11280.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NF901264 {ECO:0000313|EMBL:ADK11280.1};
RX PubMed=22890194; DOI=10.1016/j.ijantimicag.2012.06.016;
RA Wang F., Wu K., Sun J., Wang Q., Chen Q., Yu S., Rui Y.;
RT "Novel ISCR1-linked resistance genes found in multidrug-resistant Gram-
RT negative bacteria in southern China.";
RL Int. J. Antimicrob. Agents 40:404-408(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001526,
CC ECO:0000256|RuleBase:RU361140};
CC -!- SIMILARITY: Belongs to the class-A beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00009009, ECO:0000256|RuleBase:RU361140}.
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DR EMBL; DQ108615; AAZ30046.1; -; Genomic_DNA.
DR EMBL; HM175877; ADK11280.1; -; Genomic_DNA.
DR RefSeq; WP_032489926.1; NZ_KP975077.1.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030655; P:beta-lactam antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR045155; Beta-lactam_cat.
DR InterPro; IPR000871; Beta-lactam_class-A.
DR InterPro; IPR023650; Beta-lactam_class-A_AS.
DR PANTHER; PTHR35333; BETA-LACTAMASE; 1.
DR PANTHER; PTHR35333:SF3; BETA-LACTAMASE2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13354; Beta-lactamase2; 1.
DR PRINTS; PR00118; BLACTAMASEA.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS00146; BETA_LACTAMASE_A; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|RuleBase:RU361140};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361140};
KW Plasmid {ECO:0000313|EMBL:AAZ30046.1}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..291
FT /note="Beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015097050"
FT DOMAIN 49..264
FT /note="Beta-lactamase class A catalytic"
FT /evidence="ECO:0000259|Pfam:PF13354"
SQ SEQUENCE 291 AA; 30951 MW; C8CB0A7739B9469E CRC64;
MVTKRVQRMM FAAAACIPLL LGSAPLYAQT SAVQQKLAAL EKSSGGRLGV ALIDTADNTQ
VLYRGDERFP MCSTSKVMAA AAVLKQSETQ KQLLNQPVEI KPADLVNYNP IAEKHVNGTM
TLAELSAAAL QYSDNTAMNK LIAQLGGPGG VTAFARAIGD ETFRLDRTEP TLNTAIPGDP
RDTTTPRAMA QTLRQLTLGH ALGETQRAQL VTWLKGNTTG AASIRAGLPT SWTAGDKTGS
GDYGTTNDIA VIWPQGRAPL VLVTYFTQPQ QNAESRRDVL ASAARIIAEG L
//
