ID Q1AIT8_9HIV1 Unreviewed; 326 AA.
AC Q1AIT8;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AAZ84274.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AAZ84274.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AAZ84274.1}
RP NUCLEOTIDE SEQUENCE.
RA Loutfy M.R., Walmsley S.L., Raboud J.M., Montaner J.S.G., Wynhoven B.,
RA Brumme Z.L., Mo T., Smaill F., Rouleau D., Gill J., Schlech W., Gough K.,
RA Rachlis A., Cameron B., Lapointe N., Trottier B., Shafran S.,
RA Harrigan P.R.;
RT "Assay of HIV gp-41 amino acid sequence to identify baseline variation and
RT development of mutations in patients failing enfuvirtide.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; DQ076868; AAZ84274.1; -; Genomic_RNA.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000328; GP41-like.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AAZ84274.1};
KW Virion {ECO:0000313|EMBL:AAZ84274.1}.
FT DOMAIN 19..208
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 207..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAZ84274.1"
FT NON_TER 326
FT /evidence="ECO:0000313|EMBL:AAZ84274.1"
SQ SEQUENCE 326 AA; 37529 MW; DBCC36E553E05ECD CRC64;
RAALGAVFLG FLGAAGSTMG AASLTLTVQA RLLLSGIZQQ QXNLLRAIEA QQHLLQLTVW
GIKQLQARVL AVERYLRDQQ LLGIWGCSGK LICTTAVPWN TSWSNKSYNS IWDNMTWMQW
EKEIDNYTXI IYTLIEESXI QQEKNEQDLL ALDHWASLWN WFDISKWLWY IKIFIMIVGG
LIGLRIXFAV LSXVKRVRQG YSPLSFQTRL PTQRGPDRPE GTEEEGGERD RDTSIRLVDG
FLAIIWDDLR SLCLFSYHRL RDLLLIVTRI LEILGRRGWE ILKYWWSLLQ YWSQELKKSA
VSLFNAIAIA VAEGTDRIIE IAQRVG
//
