ID CIAO1_COCIM Reviewed; 473 AA.
AC Q1DR81; J3K3L2;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=Probable cytosolic iron-sulfur protein assembly protein 1 {ECO:0000255|HAMAP-Rule:MF_03037};
GN Name=CIA1 {ECO:0000255|HAMAP-Rule:MF_03037}; ORFNames=CIMG_07182;
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS;
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=RS;
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- FUNCTION: Essential component of the cytosolic iron-sulfur (Fe/S)
CC protein assembly machinery. Required for the maturation of
CC extramitochondrial Fe/S proteins. {ECO:0000255|HAMAP-Rule:MF_03037}.
CC -!- SIMILARITY: Belongs to the WD repeat CIA1 family. {ECO:0000255|HAMAP-
CC Rule:MF_03037}.
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DR EMBL; GG704912; EAS31703.3; -; Genomic_DNA.
DR RefSeq; XP_001243286.1; XM_001243285.2.
DR AlphaFoldDB; Q1DR81; -.
DR SMR; Q1DR81; -.
DR STRING; 246410.Q1DR81; -.
DR GeneID; 4561388; -.
DR KEGG; cim:CIMG_07182; -.
DR VEuPathDB; FungiDB:CIMG_07182; -.
DR InParanoid; Q1DR81; -.
DR OMA; IREIRWS; -.
DR OrthoDB; 5486866at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:InterPro.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR HAMAP; MF_03037; ciao1; 1.
DR InterPro; IPR028608; CIAO1/Cia1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19920:SF0; CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED; 1.
DR PANTHER; PTHR19920; WD40 PROTEIN CIAO1; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..473
FT /note="Probable cytosolic iron-sulfur protein assembly
FT protein 1"
FT /id="PRO_0000382512"
FT REPEAT 11..58
FT /note="WD 1"
FT REPEAT 62..104
FT /note="WD 2"
FT REPEAT 144..183
FT /note="WD 3"
FT REPEAT 191..230
FT /note="WD 4"
FT REPEAT 235..313
FT /note="WD 5"
FT REPEAT 341..380
FT /note="WD 6"
FT REPEAT 438..473
FT /note="WD 7"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 473 AA; 52568 MW; FE5B2D0038ED32DE CRC64;
MPSSTPGGSL KHLSDLTPPS QDRTWLTSSH PRLPIAATCC ADKSVRVYSL VNFTLLSTIS
GGHKRSVRSC AWKPHVKGES VLATASFDAT VGVWRRWDGF GRAERDMLGL AGGLAEADRQ
EGDDTDGDEE DEDEEWGFAV LLDGHDSEVK SVSWSSGGSL LATCSRDKSI WIWEDLEDGD
NNFETVAVLQ EHSGDVKWVA WHPEEECLAS GSYDDTIRLW REDVDDWGQV ACLRGHEGTV
WCVEWEAPTS IAGDNGDGAP TTMPIDPENG KLAPCERKKW IEERSMSGPR LVSCSDDKTI
RIWRKQPQEK PPPVQYSSIP STIRPATIDE TWIEECQLPA MHDLSIYSVA WSKKTGLIAS
TGADGRIVIY QERFTSKPPV HTTSEQDKPD SARETQKANG ERTAPSTAWE VVACVDAAHE
IYEVNHVCWA KRADQRKSQQ QNFDNSEMDH ANEEEVLLST GDDGVVRVWT LER
//
