ID Q1EQ46_ENTHI Unreviewed; 876 AA.
AC Q1EQ46; A0A175JR28; A0A5K1UJ22; C4M4C0;
DT 11-JUL-2006, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2006, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=EhSec24C {ECO:0000313|EMBL:BAE94763.1};
DE SubName: Full=Protein transport protein sec24 putative {ECO:0000313|EMBL:GAT96210.1};
GN ORFNames=CL6EHI_048310 {ECO:0000313|EMBL:GAT96210.1};
OS Entamoeba histolytica.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=5759 {ECO:0000313|EMBL:BAE94763.1};
RN [1] {ECO:0000313|EMBL:BAE94763.1}
RP NUCLEOTIDE SEQUENCE.
RA Saito-Nakano Y., Nozaki T.;
RT "Vesicular Traffic in Entamoeba histolytica.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAT96210.1, ECO:0000313|Proteomes:UP000078387}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM1:IMSS clone 6 {ECO:0000313|EMBL:GAT96210.1,
RC ECO:0000313|Proteomes:UP000078387};
RA Mukherjee Avik.K., Izumyama S., Nakada-Tsukui K., Nozaki T.;
RT "First whole genome sequencing of Entamoeba histolytica HM1:IMSS-clone-6.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the SEC23/SEC24 family. SEC24 subfamily.
CC {ECO:0000256|ARBA:ARBA00008334}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB261034; BAE94763.1; -; Genomic_DNA.
DR EMBL; BDEQ01000001; GAT96210.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1EQ46; -.
DR STRING; 5759.Q1EQ46; -.
DR EnsemblProtists; GAT96210; GAT96210; CL6EHI_048310.
DR EnsemblProtists; rna_EHI_048310-1; rna_EHI_048310-1; EHI_048310.
DR VEuPathDB; AmoebaDB:EHI5A_133510; -.
DR VEuPathDB; AmoebaDB:EHI7A_164220; -.
DR VEuPathDB; AmoebaDB:EHI8A_188520; -.
DR VEuPathDB; AmoebaDB:EHI_048310; -.
DR VEuPathDB; AmoebaDB:KM1_256560; -.
DR HOGENOM; CLU_004589_1_0_1; -.
DR InParanoid; Q1EQ46; -.
DR OMA; INPFMTF; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000078387; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IBA:GO_Central.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IBA:GO_Central.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 1.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR036465; vWFA_dom_sf.
DR InterPro; IPR006895; Znf_Sec23_Sec24.
DR InterPro; IPR036174; Znf_Sec23_Sec24_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR Pfam; PF04810; zf-Sec23_Sec24; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR SUPFAM; SSF82919; Zn-finger domain of Sec23/24; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 201..237
FT /note="Zinc finger Sec23/Sec24-type"
FT /evidence="ECO:0000259|Pfam:PF04810"
FT DOMAIN 279..499
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 509..589
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 606..684
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 98036 MW; DAD8DF144D8FECF5 CRC64;
MGDNFQQTSN FSNSFTLPGH IPTTASQPDG TTPNPSFASV PYPQQQTQQR TTTNNNMAFP
QQNMGSIPQQ TPNDQTLLQQ NIVPTQYSNQ PVQQPQVNQP VPQEKPNVDQ SSMPAPTIIS
SQPTAYNNLI TPPSSLQPFT CAVSNKSSPK NIRMSVFTPA FQGKMMKLLE IPLSCEVTPF
AKMFEGEKLE SVKVEPKNIK RCPRCGGYVN PFCTFEEGGK KMKCNLCEYL SDVDDNYFSP
LRGDGKREDT ERRIELMYGT NEYELEGKDP VYINKSCGEP MKFIFLIDVS KDSLTRVFDS
VMNVLQNALQ SVPELVKTLE CGFVTFSNYI QYWVLGSTPR MVKVCDITEP FVPLAPKNFF
KPISEVIEMI PMLNQYIRKN ITEGVINDNC LVSAIESAAQ MIGTTGKILA FTTSQPNEGT
AALIRKPSDI SSNPQTPANQ YINQMAKKLS LNCIGVDLFV LPNKFSDIVT IGEIPRYTGG
ELFYYPNYST KNQIKLTKDV LSSFDMDCGF DVEVRVRSSA GVFIQDYLGD VMPCKDMIDT
VRIGYMNSKK SIIALMDYDD ELNNYVGFFI QAVILYTDIF GQKKIKIFNG FYSTATELAD
VFKKADADVI LNTLIRQSIK AGNFSSDAGL NIELLDKTVS ILTAYRKHCS AHAKSSILLL
PEALKLVPIF VLGAMKTSAF MPFFQLNSMS TGYGINGIIS DLKFASIYQT TSISIGSLLR
QYYYNAYDVT GHLSGIVTSD NFSDDSFKVR LSEKNFAEDK VYLLDTGKDY KLLVGKNVSD
EIKTNLFGQP IDLMNNQQDF TSLVYSNALS QPDNLLTKLI YWLAGMSFTP MVALEVIPFN
KMDLSPFMLE DKTMKGVAYF DLLVYYHKKI QKKLAN
//
