ID Q1JPT9_DANRE Unreviewed; 410 AA.
AC Q1JPT9;
DT 13-JUN-2006, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2006, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Cell adhesion molecule 3 {ECO:0000313|EMBL:AAI16601.1, ECO:0000313|RefSeq:NP_001038711.1};
GN Name=cadm3 {ECO:0000313|EMBL:AAI16601.1,
GN ECO:0000313|RefSeq:NP_001038711.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060512-196};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI16601.1};
RN [1] {ECO:0000313|EMBL:AAI16601.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAI16601.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18095341; DOI=10.1002/dvdy.21397;
RA Pietri T., Easley-Neal C., Wilson C., Washbourne P.;
RT "Six cadm/SynCAM genes are expressed in the nervous system of developing
RT zebrafish.";
RL Dev. Dyn. 237:233-246(2008).
RN [3] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20802085; DOI=10.1074/mcp.m110.004119;
RA Martin S., Sollner C., Charoensawan V., Adryan B., Thisse B., Thisse C.,
RA Teichmann S., Wright G.J.;
RT "Construction of a large extracellular protein interaction network and its
RT resolution by spatiotemporal expression profiling.";
RL Mol. Cell. Proteomics 9:2654-2665(2010).
RN [4] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20935258; DOI=10.1074/mcp.m110.003020;
RA Charoensawan V., Adryan B., Martin S., Sollner C., Thisse B., Thisse C.,
RA Wright G.J., Teichmann S.A.;
RT "The impact of gene expression regulation on evolution of extracellular
RT signaling pathways.";
RL Mol. Cell. Proteomics 9:2666-2677(2010).
RN [5] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21456004;
RA Hunter P.R., Nikolaou N., Odermatt B., Williams P.R., Drescher U.,
RA Meyer M.P.;
RT "Localization of Cadm2a and Cadm3 proteins during development of the
RT zebrafish nervous system.";
RL J. Comp. Neurol. 519:2252-2270(2011).
RN [6] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26190107; DOI=10.1016/j.celrep.2015.06.047;
RA Gao X., Metzger U., Panza P., Mahalwar P., Alsheimer S., Geiger H.,
RA Maischein H.M., Levesque M.P., Templin M., Sollner C.;
RT "A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies
RT Draxin as a Secreted Netrin-1 Antagonist.";
RL Cell Rep. 12:694-708(2015).
RN [8] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [9] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [10] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [11] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29195096;
RA Tu H., Peng T., Liu J., Chen X., Fan C., Huang Z., Zhang Y., Zou F.,
RA Meng X.;
RT "Role of neurexin2a in lead-induced locomotor defect in developing
RT zebrafish.";
RL Aquat. Toxicol. 194:167-175(2018).
RN [12] {ECO:0000313|RefSeq:NP_001038711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30465971;
RA Zheng Y., Yuan J., Meng S., Chen J., Gu Z.;
RT "Testicular transcriptome alterations in zebrafish (Danio rerio) exposure
RT to 17beta-estradiol.";
RL Chemosphere 218:14-25(2019).
RN [13] {ECO:0000313|RefSeq:NP_001038711.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the nectin family.
CC {ECO:0000256|ARBA:ARBA00007810}.
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DR EMBL; BC116600; AAI16601.1; -; mRNA.
DR RefSeq; NP_001038711.1; NM_001045246.1.
DR GeneID; 692273; -.
DR KEGG; dre:692273; -.
DR AGR; ZFIN:ZDB-GENE-060512-196; -.
DR CTD; 57863; -.
DR ZFIN; ZDB-GENE-060512-196; cadm3.
DR OrthoDB; 3039994at2759; -.
DR Proteomes; UP000000437; Alternate scaffold 2.
DR Proteomes; UP000000437; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR CDD; cd05761; IgI_2_Necl-1-4; 1.
DR CDD; cd05882; IgV_1_Necl-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR003585; Neurexin-like.
DR PANTHER; PTHR45889:SF5; CELL ADHESION MOLECULE 3; 1.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR PROSITE; PS50835; IG_LIKE; 3.
PE 1: Evidence at protein level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q1JPT9};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 344..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..136
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 144..239
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 244..329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 379..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 44398 MW; 228EB4941C40B698 CRC64;
MRARRTLAFP SFQRAALRAL AAFTMILATS VRSNYVYDDD PFQPVTQDET VAVGGVVTLT
CGVKENDNSS LQWSNTAQQT LYFGEKRALR DNRIQLVKST ATELIITIGD VQLSDDGEYT
CSIFTMPVRT ARATVTVLGV PGKPVITGFE GAVQEGGKVT LTCTSSGGKP PAKLHWYRDH
VEIQGRPDVV ESNPNEPTYT VTSELTLSVS RDDNDALIAC AVDHPSIANG DKRTEQPLNV
LFSPRVSIHP ESDLPREGEK FYLQCVGNGN PEPNAFVWRR KEGELPPLAK VDGAFLRSES
LNKSDNGVYE CQADNGIGMG DVAHTLLVQD PTAMSTGSGV DHAVIGGVVA VIVFIMLCLL
LVLGRYLIRH KGTYLTHEAK GSDDAPDADT AIINAEGGHS GVDDKKEYFI
//
