ID Q1K5F4_NEUCR Unreviewed; 617 AA.
AC Q1K5F4;
DT 28-JUN-2011, integrated into UniProtKB/TrEMBL.
DT 28-JUN-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=RNA lariat debranching enzyme {ECO:0000313|EMBL:EAA27620.1};
GN ORFNames=NCU03409 {ECO:0000313|EMBL:EAA27620.1};
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110 {ECO:0000313|EMBL:EAA27620.1, ECO:0000313|Proteomes:UP000001805};
RN [1] {ECO:0000313|EMBL:EAA27620.1, ECO:0000313|Proteomes:UP000001805}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987
RC {ECO:0000313|Proteomes:UP000001805};
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.,
RA FitzHugh W., Ma L.J., Smirnov S., Purcell S., Rehman B., Elkins T.,
RA Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D.,
RA Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P., Glass L., Orbach M.J., Berglund J.A., Voelker R., Yarden O.,
RA Plamann M., Seiler S., Dunlap J., Radford A., Aramayo R., Natvig D.O.,
RA Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S.,
RA Lander E.S., Nusbaum C., Birren B.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC {ECO:0000256|ARBA:ARBA00006045}.
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DR EMBL; CM002237; EAA27620.1; -; Genomic_DNA.
DR RefSeq; XP_956856.1; XM_951763.2.
DR AlphaFoldDB; Q1K5F4; -.
DR STRING; 367110.Q1K5F4; -.
DR PaxDb; 5141-EFNCRP00000002520; -.
DR EnsemblFungi; EAA27620; EAA27620; NCU03409.
DR GeneID; 3873003; -.
DR KEGG; ncr:NCU03409; -.
DR VEuPathDB; FungiDB:NCU03409; -.
DR HOGENOM; CLU_005893_1_0_1; -.
DR InParanoid; Q1K5F4; -.
DR OMA; GIDDPLC; -.
DR OrthoDB; 1220605at2759; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008419; F:RNA lariat debranching enzyme activity; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd00844; MPP_Dbr1_N; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR007708; DBR1_C.
DR InterPro; IPR041816; Dbr1_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR12849:SF0; LARIAT DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR12849; RNA LARIAT DEBRANCHING ENZYME; 1.
DR Pfam; PF05011; DBR1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SMART; SM01124; DBR1; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000001805};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 388..545
FT /note="Lariat debranching enzyme C-terminal"
FT /evidence="ECO:0000259|SMART:SM01124"
FT REGION 255..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 67266 MW; 22692B840F9C7459 CRC64;
MSIDIQTTTQ QGVRIAVEGC GHGTLNAIYA ATEKSAKERG WDGVDLLIIG GDFQAVRNAA
DLNAMSVPKK YRELGDFHEY YSGVRKAPYL TIFVAGNHEA ASHLWELYYG GWVCPNIYYM
GAANVLRLGP LRIAGMSGIW KGYNYRKAHH ERLPFNDDDV KSFYHVREID VRKLLQLQTQ
VDIGISHDWP RAIEKHGNTK HLWNMKPDFE RESADGSLGN QAAEYVMDRL RPPYWFSAHL
HCKYSAIKTY DLPKETTSDG GETTKPEETA VPQPQEQQPA PAAANPDEID LDMEDEPAPA
PQQTAAPVAT SNPDEIDLDD DEVAPTAPSQ PAPTSAAPAA AVTEEEDPTE ALRSLLPASF
SNPNPQSSYN AQPHGGNSGN KPKPGQPVPP TITNTTVRFL SLDKCLPGRK FLQLAEIEPI
NPSPKELQRP LRLSYDPEWL SITLAFHPLL RSAVGKHCPS HPNAPIPVDL GEAGYKPLIE
EARKWVDEHI TGDKLLVPED FVQTAPPIDL VNRPETGNMT DEMPVEYTNP HTAEFCRLLG
VENYWDASEE EREGRRVQGP RPMAERFGGR GGGHRGGGRG GGGGGGGGWR GGRGGRGGGG
GRGGGGGRGR GRGRGGW
//