ID Q1L8G4_DANRE Unreviewed; 730 AA.
AC Q1L8G4; A0A8M2BC21;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 10-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Leucine-rich repeat and guanylate kinase domain-containing protein isoform X2 {ECO:0000313|RefSeq:XP_005164767.1};
DE SubName: Full=Leucine-rich repeats and guanylate kinase domain-containing {ECO:0000313|Ensembl:ENSDARP00000092387};
GN Name=lrguk {ECO:0000313|Ensembl:ENSDARP00000092387,
GN ECO:0000313|RefSeq:XP_005164767.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050419-232};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000092387};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000092387, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000092387};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000092387}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000092387};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005164767.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005164767.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX470240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR788241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005164767.1; XM_005164710.3.
DR STRING; 7955.ENSDARP00000092387; -.
DR PaxDb; 7955-ENSDARP00000092387; -.
DR Ensembl; ENSDART00000101613; ENSDARP00000092387; ENSDARG00000069698.
DR Ensembl; ENSDART00000101613.5; ENSDARP00000092387.4; ENSDARG00000069698.5.
DR GeneID; 559670; -.
DR KEGG; dre:559670; -.
DR AGR; ZFIN:ZDB-GENE-050419-232; -.
DR CTD; 136332; -.
DR ZFIN; ZDB-GENE-050419-232; lrguk.
DR eggNOG; KOG0531; Eukaryota.
DR eggNOG; KOG0707; Eukaryota.
DR HOGENOM; CLU_019293_0_0_1; -.
DR OMA; EEDGCDY; -.
DR OrthoDB; 1331402at2759; -.
DR PhylomeDB; Q1L8G4; -.
DR TreeFam; TF329158; -.
DR Proteomes; UP000000437; Chromosome 4.
DR Bgee; ENSDARG00000069698; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004385; F:guanylate kinase activity; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Kinase {ECO:0000313|RefSeq:XP_005164767.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transferase {ECO:0000313|RefSeq:XP_005164767.1}.
FT DOMAIN 315..498
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 504..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 616..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 80839 MW; 999E1DE83580ADB6 CRC64;
MEIAGELTED EVFKCLSGLG QSATGLQHTY LCLSAPGRDL KNVSILCNYI YLQKLELPYN
KIKDLSCVSH MPYLITLDAS HNQLTDFFGF QPPKNLKEVN FSHNQMTAMK DLSAYSSLTK
LILDHNSFSV IRGLEKCKRL SHLSLAHNNI SRIRGLDHLP LRELCLAGNM INKIENLQTL
HNLQVLDLSC NRIQSLTGLQ NLRFLGTVNL ESNLITEIKE AAHLHDLILL REINLLKNPV
QDHDDYRIAV IFLLQHLILL DKQTVTAEEK VAAVNKYDPP LEVVAARDHM THLVYQLMQP
QVIFDSTLPS LDAPYPMLVL TGPQACGKRE LAHKLCQEFS DYFAYGACHT TRGPYFGEED
GLDYHFVTEE EFHNMIQMGQ FIQTMQYGGH WYGLSRESIE RVAREGLACC VHMELEGVFS
LKNSYFEPRY VLLIPSVVDN YVLFLKARGF YSNAQMETAV SRIDLYARIN RERPGFFDSI
IPCDDRAEAY RSLKQLVKEY LGLEEHSGGG DSSSITPDNT STNTTGELPA ASATESTDLM
DSYSRNYQKK IQANMTPQRT EMASNHRRLQ QIREALSGKS PGAYAELFQR SVPAAPSSLA
SQSHPPAGPS SSPVRPAGLS APNLSEDSSS EESRASSGLS MRSSAGVFSA ESPARGSDAG
SGPNIEPLDI SMLGQDRDSL RGLTPDAPRP ASDRVSPTHP SSPGRPGANV KPVLPPIPSG
RKTNDSGSKQ
//
