ID   Q1LEJ6_CUPMC            Unreviewed;       426 AA.
AC   Q1LEJ6;
DT   30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT   30-MAY-2006, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Cytosine deaminase {ECO:0000313|EMBL:ABF11430.1};
DE            EC=3.5.4.1 {ECO:0000313|EMBL:ABF11430.1};
GN   Name=codA {ECO:0000313|EMBL:ABF11430.1};
GN   OrderedLocusNames=Rmet_4568 {ECO:0000313|EMBL:ABF11430.1};
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS   CH34) (Ralstonia metallidurans).
OG   Plasmid megaplasmid CH34 {ECO:0000313|Proteomes:UP000002429}.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF11430.1, ECO:0000313|Proteomes:UP000002429};
RN   [1] {ECO:0000313|Proteomes:UP000002429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC   {ECO:0000313|Proteomes:UP000002429};
RC   PLASMID=Plasmid megaplasmid CH34 {ECO:0000313|Proteomes:UP000002429};
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA   Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA   Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT   master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
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DR   EMBL; CP000353; ABF11430.1; -; Genomic_DNA.
DR   RefSeq; WP_011519018.1; NC_007974.2.
DR   AlphaFoldDB; Q1LEJ6; -.
DR   KEGG; rme:Rmet_4568; -.
DR   eggNOG; COG0402; Bacteria.
DR   HOGENOM; CLU_031758_0_1_4; -.
DR   Proteomes; UP000002429; Plasmid megaplasmid CH34.
DR   GO; GO:0102480; F:5-fluorocytosine deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004131; F:cytosine deaminase activity; IEA:UniProtKB-EC.
DR   CDD; cd01293; Bact_CD; 1.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 2.30.40.10; Urease, subunit C, domain 1; 1.
DR   InterPro; IPR013108; Amidohydro_3.
DR   InterPro; IPR011059; Metal-dep_hydrolase_composite.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   PANTHER; PTHR32027; CYTOSINE DEAMINASE; 1.
DR   PANTHER; PTHR32027:SF0; CYTOSINE DEAMINASE; 1.
DR   Pfam; PF07969; Amidohydro_3; 1.
DR   SUPFAM; SSF51338; Composite domain of metallo-dependent hydrolases; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:ABF11430.1};
KW   Plasmid {ECO:0000313|EMBL:ABF11430.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002429}.
FT   DOMAIN          40..399
FT                   /note="Amidohydrolase 3"
FT                   /evidence="ECO:0000259|Pfam:PF07969"
SQ   SEQUENCE   426 AA;  46347 MW;  575C9E4E8EFE2655 CRC64;
     MFDTILRHCN MPDGRTDIDI GIANGRIAAV EPRIAATAGE EIDAAGQLVS PPFVDAHFHM
     DSTLSYGLPR VNQSGTLLEG IALWGELKPL LTQDAIVERA LAYCDWAVSK GLLAIRSHVD
     VCDPRLLATE ALLHVRERVR PYLDLQLVAF PQDGLLRAPD ALNNLRRALD LGVDVVGGIP
     HFERTMADGA ASVKMLCEEA AERGLRVDMH CDESDDPMSR HIETLASESV RLGLQGRVTG
     SHLTSMHSMD NYYVSKLLPL MREAGVSAIA NPLINITLQG RHDTYPKRRG MTRVPEMLAA
     GIPVAFGHDC VMDPWYSLGS GDMLEVAHMG LHVAQMTGQD AMRACFTAVT ETPARILGLE
     GYGISPGRRA DLVLLQARDP VEALRLRATR LLVMRAGNVI ARTAPATAML ALAGRPAQVD
     FQLHRA
//