ID Q1LK79_CUPMC Unreviewed; 455 AA.
AC Q1LK79;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=Peptidase required for the maturation and secretion of the antibiotic peptide MccB17 {ECO:0000313|EMBL:ABF09447.1};
GN Name=pmbA {ECO:0000313|EMBL:ABF09447.1};
GN OrderedLocusNames=Rmet_2570 {ECO:0000313|EMBL:ABF09447.1};
OS Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS CH34) (Ralstonia metallidurans).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF09447.1, ECO:0000313|Proteomes:UP000002429};
RN [1] {ECO:0000313|Proteomes:UP000002429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC {ECO:0000313|Proteomes:UP000002429};
RX PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT master survivalist in harsh and anthropogenic environments.";
RL PLoS ONE 5:E10433-E10433(2010).
CC -!- SIMILARITY: Belongs to the peptidase U62 family.
CC {ECO:0000256|ARBA:ARBA00005836}.
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DR EMBL; CP000352; ABF09447.1; -; Genomic_DNA.
DR RefSeq; WP_011517150.1; NC_007973.1.
DR AlphaFoldDB; Q1LK79; -.
DR STRING; 266264.Rmet_2570; -.
DR GeneID; 60820986; -.
DR KEGG; rme:Rmet_2570; -.
DR eggNOG; COG0312; Bacteria.
DR HOGENOM; CLU_026425_0_0_4; -.
DR Proteomes; UP000002429; Chromosome.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.2290.10; PmbA/TldD superfamily; 1.
DR InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR InterPro; IPR047657; PmbA.
DR InterPro; IPR035068; TldD/PmbA_N.
DR InterPro; IPR036059; TldD/PmbA_sf.
DR PANTHER; PTHR43421; METALLOPROTEASE PMBA; 1.
DR PANTHER; PTHR43421:SF1; METALLOPROTEASE PMBA; 1.
DR Pfam; PF01523; PmbA_TldD_1st; 1.
DR Pfam; PF19290; PmbA_TldD_2nd; 1.
DR Pfam; PF19289; PmbA_TldD_3rd; 1.
DR SUPFAM; SSF111283; Putative modulator of DNA gyrase, PmbA/TldD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002429}.
FT DOMAIN 41..101
FT /note="Metalloprotease TldD/E N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01523"
FT DOMAIN 129..235
FT /note="Metalloprotease TldD/E central"
FT /evidence="ECO:0000259|Pfam:PF19290"
FT DOMAIN 242..454
FT /note="Metalloprotease TldD/E C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19289"
SQ SEQUENCE 455 AA; 48541 MW; 5543F86F431EC8A3 CRC64;
MSQTAEQTAH FTYTQDQLKA MAADVLRVAR ELGATDAATE ISEGSGLSVS VRKGEVETIE
QNRDKVVGVT VMIGKRRGNA STSDFSAAAL RATAEAAYNI ARFTAEDDCA GLAEEELLER
DPQDLDLFHP WTIDAEGAID IARRAEAAAF AVSPKIRNSD GASVSAQHSQ FVLATSRGFS
GGYPYSRHFI SCAPIAGSGG GMQRDDWYSS KRAPGALAEP EAIGRYAAER ALARLNARKL
STRKCPVLFE APLAAGLLGA FVQAVSGGAL YRKSTFLYDT LGKEVFAPHI QVYERPHVPG
AMGSAPFDEE GVRTHERDVV RDGVVQGYFL STYSARKLGM KTTGNAGGSH NLTLTSSQTQ
AGDDFVGMLK KMGTGLLVTE LMGQGVNYVT GDYSRGASGY WVENGVIQYP VEEITIAGNM
VEMLRQIVAV GADALVRGTK ETGSILIEQM TIAGN
//
