ID Q1LN05_CUPMC Unreviewed; 633 AA.
AC Q1LN05;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Propionate catabolism activator {ECO:0000313|EMBL:ABF08471.1};
GN Name=prpR {ECO:0000313|EMBL:ABF08471.1};
GN OrderedLocusNames=Rmet_1588 {ECO:0000313|EMBL:ABF08471.1};
OS Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 /
OS CH34) (Ralstonia metallidurans).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=266264 {ECO:0000313|EMBL:ABF08471.1, ECO:0000313|Proteomes:UP000002429};
RN [1] {ECO:0000313|Proteomes:UP000002429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34
RC {ECO:0000313|Proteomes:UP000002429};
RX PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N., Michaux A.,
RA Benotmane M.A., Leys N., Vallaeys T., Lapidus A., Monchy S., Medigue C.,
RA Taghavi S., McCorkle S., Dunn J., van der Lelie D., Mergeay M.;
RT "The complete genome sequence of Cupriavidus metallidurans strain CH34, a
RT master survivalist in harsh and anthropogenic environments.";
RL PLoS ONE 5:E10433-E10433(2010).
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DR EMBL; CP000352; ABF08471.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1LN05; -.
DR STRING; 266264.Rmet_1588; -.
DR KEGG; rme:Rmet_1588; -.
DR eggNOG; COG3829; Bacteria.
DR HOGENOM; CLU_000445_8_5_4; -.
DR Proteomes; UP000002429; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000156; F:phosphorelay response regulator activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0019629; P:propionate catabolic process, 2-methylcitrate cycle; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.10660; PrpR receptor domain-like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR012704; Sig_transdc_resp-reg_PrpR.
DR InterPro; IPR010524; Sig_transdc_resp-reg_PrpR_N.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR NCBIfam; TIGR02329; propionate_PrpR; 1.
DR PANTHER; PTHR32071:SF21; PROPIONATE CATABOLISM OPERON REGULATORY PROTEIN; 1.
DR PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF06506; PrpR_N; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF159800; PrpR receptor domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002429};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 186..233
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 315..546
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
SQ SEQUENCE 633 AA; 68361 MW; CF5BFE93B97FBF19 CRC64;
MGISRLSRAF AELIPAYAGR AEFRIVGRAF EAAASAINRE ARENRVDVVV AGGSNGAYLR
QHVDVPVVLV KVTGFDVMSA LATARRISPK VALVTHASTY AEVDEFVRAF SLDIPRYTYL
TEDDATARVR ALKEEGVRVV VGPGLVTDMA DKYGLVGVFL YSGNAVRLAL EDAIEAARLR
RIESTRREYV NTILAHLNEG VAAVDGEGRV QAFNPAMERF LGTPAGVAVG RKLSTLAPGL
SLDGVMQSGA RELEAIHRLG DKMVVVNRIP IMSEAGTTGA VLTIQDANAI HRADRNLRSR
TRARAAGVRY SLDDLAGDSP AMSDLRALAR RYAMVDSTVL VSGESGTGKE VLAQGMHDAS
PRRAFPFVAV NCAAFPETLL ESELFGYEEG AFTGARRGGK AGLFESAHNG TLFLDEIGDM
PPALQTRLLR VLQEKQVLPI GAIEAVPVNV RVIAATHRDL AALVRDGAFR QDLYYRLNIL
RIEMPPLRDR AGDLPVLAEL LYRRAQERLG MSDGEPLPAI VRARLARYVW PGNIRELENV
TERIAVLVAG ANLTPVALQR ELQAAVPELF SGDHGTAIEM SDGVPAQSLA GVAKASQAEH
IRRVLADCGG NRAAACAQLG ISPTTLWRRL REE
//
