ID Q1NAZ0_SPHSS Unreviewed; 527 AA.
AC Q1NAZ0;
DT 30-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 30-MAY-2006, sequence version 1.
DT 13-SEP-2023, entry version 49.
DE SubName: Full=Secretion protein HlyD {ECO:0000313|EMBL:EAT08078.1};
GN ORFNames=SKA58_07675 {ECO:0000313|EMBL:EAT08078.1};
OS Sphingomonas sp. (strain SKA58).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=314266 {ECO:0000313|EMBL:EAT08078.1, ECO:0000313|Proteomes:UP000005395};
RN [1] {ECO:0000313|EMBL:EAT08078.1, ECO:0000313|Proteomes:UP000005395}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SKA58 {ECO:0000313|EMBL:EAT08078.1,
RC ECO:0000313|Proteomes:UP000005395};
RA Hagstrom A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAT08078.1}.
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DR EMBL; AAQG01000012; EAT08078.1; -; Genomic_DNA.
DR AlphaFoldDB; Q1NAZ0; -.
DR STRING; 314266.SKA58_07675; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_14_1_5; -.
DR Proteomes; UP000005395; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005395};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 40..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..300
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 373..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 148..216
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 468..490
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..527
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 527 AA; 54672 MW; 0643DAB6258CBD71 CRC64;
MRWAAAGRAW TTAPMSNDMT TDQDLNDFLG AKPEKPWRKW VIRGGIGIAL LIAILLIARC
FGGDDKPNYA TRAVRQGDLT VTVSATGNLK PINQVDVGSE QSGKITQVYV DVNDRVTRGQ
KLAELDTRRL VDTVNQNRAQ VASSQASVAQ AQAQVALAKA TLDRQENVFK LSGGRVPAKT
ELDAARADYQ SAIANLRSAQ AQVTASQAQL SSAQTNLSIA QIVSPVTGVV LSRDIEPGQT
VAASLNAPVL FTIAEDLTQM EVEVAVDEAD VGQVKEGQSA TFAVDAFPGR SFPAKVTRVN
VGSNASSSAS SSSTSSSSSS TTGTVVAYTA VLSVNNQDEI LRPGMTATAD IVTQELHDVL
LVPNSALRFK PSSGASDGGG ITSVLPGPRR FRRGGNRQVN FGAGSSQTVY VLGEDGNPKP
VQVVVGASDG SRTVITGGDL KSGMKVITGQ LAAGQEAPAE DQKADAGNTQ DKGTGQRPRN
PSTDGSPASM GKLGNSGDAA PETAPVAPTQ GQSEPTETRG TGRQSGT
//
