ID Q1QAB8_PSYCK Unreviewed; 1182 AA.
AC Q1QAB8;
DT 16-MAY-2006, integrated into UniProtKB/TrEMBL.
DT 16-MAY-2006, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Pcryo_1608 {ECO:0000313|EMBL:ABE75385.1};
OS Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378
OS / K5).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC Psychrobacter.
OX NCBI_TaxID=335284 {ECO:0000313|EMBL:ABE75385.1, ECO:0000313|Proteomes:UP000002425};
RN [1] {ECO:0000313|Proteomes:UP000002425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5
RC {ECO:0000313|Proteomes:UP000002425};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Bruce D.,
RA Han C., Tapia R., Sims D.R., Gilna P., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Richardson P.;
RT "Complete sequence of chromosome of Psychrobacter cryohalolentis K5.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP000323; ABE75385.1; -; Genomic_DNA.
DR RefSeq; WP_011513934.1; NC_007969.1.
DR AlphaFoldDB; Q1QAB8; -.
DR STRING; 335284.Pcryo_1608; -.
DR REBASE; 16342; PcrKORF1608P.
DR KEGG; pcr:Pcryo_1608; -.
DR eggNOG; COG0827; Bacteria.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_007510_1_0_6; -.
DR Proteomes; UP000002425; Chromosome.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR047939; BREX_1_PglX.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR InterPro; IPR046816; MmeI_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033452; BREX_1_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF07669; Eco57I; 1.
DR Pfam; PF20473; MmeI_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 287..352
FT /note="MmeI-like DNA-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF20473"
FT DOMAIN 460..548
FT /note="Type II methyltransferase M.TaqI-like"
FT /evidence="ECO:0000259|Pfam:PF07669"
SQ SEQUENCE 1182 AA; 137185 MW; 40C816B3320731B5 CRC64;
METTKLKKFA QQARVTLIEQ VATKLKFVRA EESLARRENP IAVKKLEELI KQQSEQEIVE
RIAYIWFNRF CALRFMDMNR YNRSLVVSAA ADDTQPEVLA LAKAGDIDER VVSEPVREQI
LNLLNGRAPS QNPEAEVYRL LLVAYCNQWH ESMPFLFQRI DDYTELLMPD DLLSSSSVLT
DMREAMPASA CKDVEVIGWL YQFYISDKKD DVFARLKKNE KVTPENIPAA TQLFTPHWIV
RYLVENSLGR LWLLNHPESK LADSMEYYIK PADDNDDSDY LKVARPEDLK ICDPACGSGH
MLTYAFDLLY AIYEEQGYGA ADIPSLILTH NLYGIEIDER AGELAAFALT MKARDRHRRF
FNTDVRPNIC VLEPISFDDD ELDEYMDFIG RDIFTADLEE TLRQFDEVDN FGSLIRPKLK
NVAEILEQLE ATDVSGQLFL GHTHQKVLKL LKQADYLSPQ YHVVVANPPY MGGSGMNNRL
KAWAKKEFPN SKSDLFAMFI ERSLDLVCNQ GLVAMITMHS WMFLSSFKEL REQLLNQVTI
TSMAHLGSRA FDSIGGEVVQ TTAFIMKKLS DLDYKGNYLR LVDGNSEFQK NRMILEISEE
KKFNNLYQSS ANDFKKIPGR PITYWISKPY IDCYDNGELI KDVFPAKLGM RTGDNAKWLR
LWYETSLIKC SFSDLNSDQD IQLPKSWFPY NKGGEFRRWY GNNEFLVFWE NDGYDIKEET
LIKYPQLSWD NLGWKITNES DFFKKSLTWS FISSNSFGVR CSLGGAIFDV GGSSIFPEGD
NYYLAAGYLC SKICFEFLKA TNPTLNFQVV NINNLPWIQL DEENCKRVNE LVKKLVEYSK
FDWDSYETSW DFTTLTLLEE KYRKSNLADT YKGLRTHWQQ MTNDMQHLEE ENNRIFIDAY
GLQDELTPDV PLKEMTLTSN PYYRYGGVKT DDELEALLLA DTMRELISYA VGCMFGRYSL
DKPGLILANQ GDKIEQYFEQ IPDPSFMPDK NNVIPILDDG WFSDDIVERF RKFIKVAFGE
EQYESNMQFI EQSLGKNDKP RDIRDYFLKD FYDDHVKRYK KRPIYWLFTS GNFSALIYMH
RYQPDTVSIV LNDYLREFRT KLNAYKDQLD TIKISSSQSQ SEKTKAIKKL ETTTKMITEM
EEYERDVLYP LATKQIDIDL DDGVKVNYPK FGKALKKVTG LS
//
